肠炎沙门氏菌中MviA反应调节因子对igaA和Rcs系统的调控
Regulation of igaA and the Rcs system by the MviA response regulator in Salmonella enterica.
作者信息
García-Calderón Clara B, Casadesús Josep, Ramos-Morales Francisco
机构信息
Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Avda Reina Mercedes, 6, 41012 Seville, Spain.
出版信息
J Bacteriol. 2009 Apr;191(8):2743-52. doi: 10.1128/JB.01519-08. Epub 2009 Feb 13.
Abstract
IgaA is a membrane protein that prevents overactivation of the Rcs regulatory system in enteric bacteria. Here we provide evidence that igaA is the first gene in a sigma(70)-dependent operon of Salmonella enterica serovar Typhimurium that also includes yrfG, yrfH, and yrfI. We also show that the Lon protease and the MviA response regulator participate in regulation of the igaA operon. Our results indicate that MviA regulates igaA transcription in an RpoS-dependent manner, but the results also suggest that MviA may regulate RcsB activation in an RpoS- and IgaA-independent manner.
摘要
IgaA是一种膜蛋白，可防止肠道细菌中Rcs调节系统过度激活。在此，我们提供证据表明，igaA是鼠伤寒沙门氏菌σ⁷⁰依赖操纵子中的第一个基因，该操纵子还包括yrfG、yrfH和yrfI。我们还表明，Lon蛋白酶和MviA反应调节因子参与igaA操纵子的调控。我们的结果表明，MviA以RpoS依赖的方式调节igaA转录，但结果也表明，MviA可能以RpoS和IgaA独立的方式调节RcsB激活。
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