Carballo J, Ferreirós C M, Criado M T
Departamento de Microbiologia y Parasitologia, Facultad de Farmacia, Universitad de Santiago.
Med Microbiol Immunol. 1991;180(3):149-55. doi: 10.1007/BF00206119.
The use of intravascular catheters is frequently associated with coagulase-negative staphylococcal infections. Colonization of catheters depends on the ability of bacteria to attach to artificial surfaces, this process is affected by macromolecules present in the body fluids. We determined the adherence of five coagulase-negative strains onto polyethylene, nylon and polyvinyl-chloride catheters, after treatment of bacteria, catheters or both with citrated human plasma, human serum albumin or fibrinogen. Plasma and serum albumin produced a marked inhibition of bacterial adherence (P less than 0.05) by means of adsorption on biomaterial surface. Fibrinogen enhanced (P less than 0.05) the number of bound bacteria, specially through its interaction with the staphylococcal surface. These observations suggest the possible role of plasma proteins in these infections.
血管内导管的使用常常与凝固酶阴性葡萄球菌感染相关。导管的定植取决于细菌附着于人工表面的能力，这一过程受体液中大分子物质的影响。我们测定了五株凝固酶阴性菌株在经柠檬酸盐处理的人血浆、人血清白蛋白或纤维蛋白原处理细菌、导管或两者后，在聚乙烯、尼龙和聚氯乙烯导管上的黏附情况。血浆和血清白蛋白通过吸附在生物材料表面，对细菌黏附产生了显著抑制作用（P<0.05）。纤维蛋白原增加了（P<0.05）黏附细菌的数量，特别是通过其与葡萄球菌表面的相互作用。这些观察结果提示血浆蛋白在这些感染中可能发挥的作用。
