Gorska K, Krenke R, Korczynski P, Kosciuch J, Domagala-Kulawik J, Chazan R
Department of Internal Medicine, Pneumology and Allergology, Medical University of Warsaw, Warsaw, Poland.
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:261-70.
Eosinophilic airway inflammation is regarded as a typical feature of asthma, while in chronic obstructive pulmonary disease (COPD) neutrophils seem predominant inflammatory airway cells. The aim of the present study was to compare the cellular components of airway inflammation in patients with newly diagnosed mild or moderate COPD and asthma. Seventeen patients with COPD (M/F 10/7, aged 57 +/-11 yr) and 22 patients with asthma (M/F 12/10, aged 36 +/-14 yr) were enrolled into the study. None of the patients has been treated with steroids for at least 3 months. All patients underwent clinical examination, laboratory examinations, skin-prick tests, pulmonary function tests, methacholine challenge test, and sputum induction with the total and differential cell count assessments. We found increased number of eosinophils in both study groups. However, there were no significant differences in the cellular composition of induced sputum between the asthma and COPD patients. We conclude that eosinophils are important inflammatory cells not only in asthma, but also in COPD.
嗜酸性气道炎症被视为哮喘的典型特征，而在慢性阻塞性肺疾病（COPD）中，中性粒细胞似乎是主要的气道炎症细胞。本研究的目的是比较新诊断的轻度或中度COPD患者与哮喘患者气道炎症的细胞成分。17例COPD患者（男/女10/7，年龄57±11岁）和22例哮喘患者（男/女12/10，年龄36±14岁）纳入本研究。所有患者至少3个月未接受过类固醇治疗。所有患者均接受了临床检查、实验室检查、皮肤点刺试验、肺功能测试、乙酰甲胆碱激发试验以及诱导痰检查，并进行了总细胞计数和分类细胞计数评估。我们发现两个研究组中的嗜酸性粒细胞数量均增加。然而，哮喘患者和COPD患者诱导痰的细胞组成没有显著差异。我们得出结论，嗜酸性粒细胞不仅在哮喘中，而且在COPD中都是重要的炎症细胞。
