Tonhajzerova I, Javorka M, Trunkvalterova Z, Chroma O, Javorkova J, Lazarova Z, Ciljakova M, Javorka K
Institute of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin Faculty Hospital, Martin, Slovakia.
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:709-18.
We aimed to test whether the evaluation of the cardio-respiratory interaction using the analysis of heart rate and blood pressure variabilities and respiratory maneuvers can reveal cardiovagal dysfunction in obese adolescents 12-18 years old. The spectral power in high frequency band of the heart rate variability (HRV) reflecting respiratory sinus arrhythmia was used as an index of the cardiac vagal control, and the spectral power in high frequency band of the blood pressure variability (BPV) as an indicator of mechanical effects of respiration. The deep breathing test and Valsalva maneuver were applied. The obese group had a reduction in spectral power in high frequency band of the HRV. Differences in high frequency band spectral power of the BPV between the obese and control groups were not found. The finding of lower respiratory sinus arrhythmia, indicating a cardiovagal dysfunction in obese adolescents, can provide important diagnostic information about early subclinical autonomic dysfunction in obesity.
我们旨在测试，通过分析心率变异性、血压变异性以及呼吸动作来评估心肺相互作用，是否能够揭示12至18岁肥胖青少年的心脏迷走神经功能障碍。反映呼吸性窦性心律不齐的心率变异性（HRV）高频带中的频谱功率被用作心脏迷走神经控制的指标，而血压变异性（BPV）高频带中的频谱功率则作为呼吸机械效应的指标。应用了深呼吸试验和瓦尔萨尔瓦动作。肥胖组HRV高频带的频谱功率降低。未发现肥胖组和对照组之间BPV高频带频谱功率的差异。较低的呼吸性窦性心律不齐这一发现表明肥胖青少年存在心脏迷走神经功能障碍，可为肥胖早期亚临床自主神经功能障碍提供重要的诊断信息。
