Trullenque-Eriksson Anna, Muñoz-Corcuera Marta, Campo-Trapero Julián, Cano-Sánchez Jorge, Bascones-Martínez Antonio
Dentistry graduate, Official Master in Dentistry Science, Universidad Complutense de Madrid, Spain.
Med Oral Patol Oral Cir Bucal. 2009 May 1;14(5):E210-6.
The objective of this study was to analyse publications related to examination techniques that might improve the visualisation of suspicious lesions of the oral mucosa (ViziLite system and VELscope system) or that might facilitate the cytological identification of suspicious lesions (OralCDx).
A literature search was performed, using the PubMed database and the key words "brush biopsy", "OralCDx", "ViziLite" and "Velscope", limiting the search to papers in English or Spanish published from 2002 to 2008.
According to the results of studies identified, the ViziLite system has a sensitivity of 100% and specificity ranging from 0-14.2%, the VELscope system has a sensitivity of 98-100% and specificity of 94-100% and the Oral CDx system has a sensitivity of 71.4-100% and specificity of 32-100%.
Clinical examination and histopathological confirmation with biopsy remain the gold standard for the detection of oral cancer. More randomised controlled studies are needed to confirm the positive cost-benefit relationship and the true usefulness of these "new diagnostic methods" in oral mucosal pathology.
本研究的目的是分析与可能改善口腔黏膜可疑病变可视化的检查技术（ViziLite系统和VELscope系统）或可能有助于可疑病变细胞学鉴定的技术（OralCDx）相关的出版物。
利用PubMed数据库进行文献检索，关键词为“刷检活检”“OralCDx”“ViziLite”和“Velscope”，检索范围限定为2002年至2008年发表的英文或西班牙文论文。
根据所确定研究的结果，ViziLite系统的灵敏度为100%，特异度为0 - 14.2%；VELscope系统的灵敏度为98 - 100%，特异度为94 - 100%；Oral CDx系统的灵敏度为71.4 - 100%，特异度为32 - 100%。
临床检查及活检组织病理学确诊仍是口腔癌检测的金标准。需要更多随机对照研究来证实这些“新诊断方法”在口腔黏膜病理学中的成本效益正相关关系及真正效用。
