König H J, Anagnostopoulos-Schleep J, Mewe R
Klinik und Poliklinik für Neurochirugie der Westfäilschen Wilhelms-Universität Münster.
Med Klin (Munich). 1991 Jul 15;86(7):333-7, 382.
During the last two years oral contraceptives containing gestodene were suspected to cause cerebrovascular disorders. 52 cases with adverse neurological side effects were registered up to October 31, 1990. Anonymous protocols received from the Companies Schering AG and Wyeth Pharma were analyzed from a clinical point of view. There are different arterial and venous, thrombotic and embolic disorders caused by different pathogenetic principles. Only one third of the cases was documented by neuro-imaging to render possible actual diagnostic reliability. Suspected cases represent a great number of different cerebrovascular disorders usually observed in neurological and neurosurgical series, concerning both men and women, OC-users and non users.
在过去两年中，含孕二烯酮的口服避孕药被怀疑会引发脑血管疾病。截至1990年10月31日，共记录了52例有不良神经副作用的病例。从临床角度对先灵公司和惠氏制药公司提供的匿名记录进行了分析。不同的发病机制导致了不同的动静脉、血栓形成和栓塞性疾病。只有三分之一的病例有神经影像学记录，以确保实际诊断的可靠性。疑似病例代表了大量通常在神经科和神经外科病例中观察到的不同脑血管疾病，涉及男性和女性、口服避孕药使用者和非使用者。
