Godineau Edouard, Landais Yannick
University Bordeaux-1, Institut des Sciences Moléculaires, ISM-UMR 5255, 351, cours de la libération 33405 Talence Cedex, France.
Chemistry. 2009;15(13):3044-55. doi: 10.1002/chem.200802415.
All in one pot! Radical, radical-ionic, and radical-organometallic MCR are highly convergent processes, representing a useful pathway to molecular and structural diversity (see scheme). This concept article highlights recent developments in the field and shows the potential of the strategy for the economical elaboration of various kinds of organic substrates.Progress in multicomponent reactions (MCRs) based on ionic and organometallic processes has recently allowed the synthesis, with high efficiency, of large collections of drug-like molecules. In contrast, MCRs based on cascade radical reactions appear to have attracted, so far, much less interest. This concept article highlights the latest progress in the field and underlines the potential of such an approach. The collected examples demonstrate that radical and radical-ionic MCRs are highly convergent processes leading to useful structural diversity.
一锅搞定！自由基、自由基-离子型和自由基-有机金属多组分反应（MCR）是高度汇聚的过程，是实现分子和结构多样性的有效途径（见图式）。这篇概念文章重点介绍了该领域的最新进展，并展示了该策略在经济地合成各种有机底物方面的潜力。基于离子和有机金属过程的多组分反应（MCR）的进展最近使得高效合成大量类药物分子成为可能。相比之下，基于级联自由基反应的MCR迄今为止似乎吸引力要小得多。这篇概念文章重点介绍了该领域的最新进展，并强调了这种方法的潜力。收集的实例表明，自由基和自由基-离子型MCR是导致有用结构多样性的高度汇聚过程。
