Sumino Shuhei, Fukuyama Takahide, Sasano Mika, Ryu Ilhyong, Jacquet Antoine, Robert Frédéric, Landais Yannick
Department of Chemistry, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
Department of Applied Chemistry, National Chiao Tung University, Hsinchu, Taiwan.
Beilstein J Org Chem. 2019 Jul 31;15:1822-1828. doi: 10.3762/bjoc.15.176. eCollection 2019.
Four-component coupling reactions between xanthogenates, alkenes, CO, and sulfonyl oxime ethers were studied. In the presence of hexabutylditin, working as a propagating radical reagent, the chain reaction proceeds, as expected, taking into account reagents polarities, affording the corresponding functionalized α-keto oximes. Although yields are modest, this rare one-pot four-component process is easy to carry out and the resulting compounds, bearing multiple functionalities, have the potential for further elaboration.
研究了黄原酸酯、烯烃、一氧化碳和磺酰基肟醚之间的四组分偶联反应。在用作链增长自由基试剂的六丁基二锡存在下，考虑到试剂的极性，链反应按预期进行，得到相应的官能化α-酮肟。尽管产率一般，但这种罕见的一锅四组分过程易于实施，且所得的具有多种官能团的化合物具有进一步衍生化的潜力。
