Olson E N, Brennan T J, Chakraborty T, Cheng T C, Cserjesi P, Edmondson D, James G, Li L
Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Mol Cell Biochem. 1991;104(1-2):7-13. doi: 10.1007/BF00229797.
Insight into the molecular mechanisms that control establishment of the skeletal muscle phenotype has recently been obtained through cloning of a family of muscle-specific regulatory factors that can activate myogenesis when transfected into non-muscle cells. This family of factors, which includes MyoD, myogenin, myf-5, and MRF4, can bind DNA and transactivate muscle-specific genes in collaboration with ubiquitous cellular factors. Growth factors play an antagonistic role in myogenesis by suppressing the actions of the myogenic regulatory factor family. This review will focus on the regulation and mechanism of action of this family of myogenic regulatory factors and on the central role of peptide growth factors in modulating their expression and biological activities.
最近，通过克隆一族肌肉特异性调节因子，对控制骨骼肌表型建立的分子机制有了深入了解。将这些因子转染到非肌肉细胞中时，它们能够激活肌生成。这个因子家族包括MyoD、肌细胞生成素、myf-5和MRF4，它们可以与普遍存在的细胞因子协同结合DNA并反式激活肌肉特异性基因。生长因子通过抑制肌源性调节因子家族的作用在肌生成中发挥拮抗作用。本综述将聚焦于这一族肌源性调节因子的调控和作用机制，以及肽生长因子在调节它们的表达和生物学活性方面的核心作用。
