Morrow Carl A, Fraser James A
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
FEMS Yeast Res. 2009 Mar;9(2):161-77. doi: 10.1111/j.1567-1364.2008.00475.x.
Many fungi in the Basidiomycota have a dimorphic life cycle, where a monokaryotic yeast form alternates with a dikaryotic hyphal form. Most of the dimorphic basidiomycetes are pathogenic on plants, animals or other fungi. In these species, infection of a host appears to be closely linked to both dimorphism and the process of sexual reproduction. Sex in fungi is governed by a specialized region of the genome known as the mating type locus that confers cell-type identity and regulates progression through the sexual cycle. Here we investigate sexual reproduction and lifestyle in emerging human pathogenic yeasts and plant pathogenic smuts of the Basidiomycota and examine the relationship among sex, dimorphism and pathogenesis.
担子菌门中的许多真菌具有双态生命周期，其中单核酵母形式与双核菌丝形式交替出现。大多数双态担子菌对植物、动物或其他真菌具有致病性。在这些物种中，宿主的感染似乎与双态性和有性生殖过程密切相关。真菌中的性别由基因组的一个特殊区域控制，该区域称为交配型位点，它赋予细胞类型身份并调节有性周期的进程。在这里，我们研究担子菌门新兴人类致病酵母和植物致病黑粉菌的有性生殖和生活方式，并研究性别、双态性和致病性之间的关系。
