McGlynn Katherine A, Quraishi Sabah M, Graubard Barry I, Weber Jean-Philippe, Rubertone Mark V, Erickson Ralph L
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA.
Cancer Res. 2009 Mar 1;69(5):1901-9. doi: 10.1158/0008-5472.CAN-08-3935. Epub 2009 Feb 17.
Exposure to endocrine-disrupting chemicals, such as polychlorinated biphenyls (PCB), may alter hormonal balance and thereby increase risk of testicular germ cell tumors (TGCT). To study the relationship of PCBs to TGCT, prediagnostic serum samples from 736 cases and 913 controls in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Adjusted odds ratios and 95% confidence intervals were estimated using logistic regression. PCB levels were examined in association with all TGCT and, separately, with each histologic type (seminoma and nonseminoma). Risks associated with seven functional groupings of PCBs, as well as sum of PCBs, were also examined. There were significantly decreased risks of TGCT in association with eight PCBs (PCB-118, PCB-138, PCB-153, PCB-156, PCB-163, PCB-170, PCB-180, and PCB-187) and no association with the remaining three (PCB-99, PCB-101, and PCB-183). The same eight congeners were significantly associated with decreased risk of nonseminoma, whereas five (PCB-138, PCB-153, PCB-156, PCB-163, and PCB-170) were associated with decreased risk of seminoma. All functional groupings of PCBs were also associated with decreased risk of TGCT and of nonseminoma, whereas six of the seven functional groups were associated with decreased risk of seminoma. Sum of PCBs was significantly associated with decreased risk of TGCT (P(trend) = 0.006), nonseminoma (P(trend) = 0.007), and seminoma (P(trend) = 0.05). Overall, these data do not support the hypothesis that PCB exposure increases the risk of TGCT.
接触多氯联苯（PCB）等内分泌干扰化学物质可能会改变激素平衡，从而增加睾丸生殖细胞肿瘤（TGCT）的风险。为了研究多氯联苯与睾丸生殖细胞肿瘤的关系，对军人睾丸肿瘤环境与内分泌决定因素研究中736例病例和913例对照的诊断前血清样本进行了分析。使用逻辑回归估计调整后的比值比和95%置信区间。研究了多氯联苯水平与所有睾丸生殖细胞肿瘤的关系，并分别研究了与每种组织学类型（精原细胞瘤和非精原细胞瘤）的关系。还研究了与多氯联苯的七个功能分组以及多氯联苯总量相关的风险。与八种多氯联苯（PCB - 118、PCB - 138、PCB - 153、PCB - 156、PCB - 163、PCB - 170、PCB - 180和PCB - 187）相关的睾丸生殖细胞肿瘤风险显著降低，与其余三种（PCB - 99、PCB - 101和PCB - 183）无关。相同的八种同系物与非精原细胞瘤风险降低显著相关，而五种（PCB - 138、PCB - 153、PCB - 156、PCB - 163和PCB - 170）与精原细胞瘤风险降低相关。多氯联苯的所有功能分组也与睾丸生殖细胞肿瘤和非精原细胞瘤风险降低相关，而七个功能组中的六个与精原细胞瘤风险降低相关。多氯联苯总量与睾丸生殖细胞肿瘤（P趋势 = 0.006）、非精原细胞瘤（P趋势 = 0.007）和精原细胞瘤（P趋势 = 0.05）风险降低显著相关。总体而言，这些数据不支持多氯联苯暴露会增加睾丸生殖细胞肿瘤风险这一假设。
