坦桑尼亚和德国不孕患者体内持久性有机氯污染物的分布情况。
Distribution of persistent organochlorine contaminants in infertile patients from Tanzania and Germany.
作者信息
Weiss Jürgen M, Bauer Otmar, Blüthgen Albrecht, Ludwig Annika K, Vollersen Elke, Kaisi Malise, Al-Hasani Safaa, Diedrich Klaus, Ludwig Michael
机构信息
Department of Obstetrics and Gynecology, University Clinic Luebeck, Ratzeburger Allee 160, D-23538, Luebeck, Germany.
出版信息
J Assist Reprod Genet. 2006 Sep-Oct;23(9-10):393-9. doi: 10.1007/s10815-006-9069-6. Epub 2006 Oct 4.
PURPOSE
To test whether environmental pollutants could affect fertility in humans.
METHODS
31 women and 16 men from Tanzania and 21 couples from Germany were included (n = 89). Pesticides and polychlorinated biphenyls were measured in serum, follicular fluid or seminal plasma by gaschromatography and related to sperm quality and pregnancy rates.
RESULTS
Higher concentrations of DDT+DDE and dieldrin in Tanzania and higher concentrations of PCBs in Germany and in men were detected. All compounds showed higher concentrations in serum and lowest concentrations in seminal plasma. A lower pregnancy rate in German women with high serum concentrations of DDT+DDE was observed. The toxins had no impact on sperm quality.
CONCLUSIONS
The distribution of toxins between agricultural and industrial countries is different. Seminal plasma seems to be inert against chemicals. In patients with high serum concentrations of DDT and DDE pregnancy rates were impaired.
目的
测试环境污染物是否会影响人类生育能力。
方法
纳入了来自坦桑尼亚的31名女性和16名男性以及来自德国的21对夫妇（n = 89）。通过气相色谱法测定血清、卵泡液或精液血浆中的农药和多氯联苯，并将其与精子质量和妊娠率相关联。
结果
在坦桑尼亚检测到较高浓度的滴滴涕+滴滴伊以及狄氏剂，在德国和男性中检测到较高浓度的多氯联苯。所有化合物在血清中的浓度较高，在精液血浆中的浓度最低。观察到血清中滴滴涕+滴滴伊浓度高的德国女性妊娠率较低。这些毒素对精子质量没有影响。
结论
农业国家和工业国家毒素的分布不同。精液血浆似乎对化学物质具有惰性。血清中滴滴涕和滴滴伊浓度高的患者妊娠率受损。
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