Lee Nam-Seob, Jeong Young-Gil
Department of Anatomy, College of Medicine, Konyang University, Seo-gu, Daejeon 302-718, South-Korea.
Cerebellum. 2009 Sep;8(3):155-62. doi: 10.1007/s12311-009-0096-6. Epub 2009 Feb 18.
The Pogo (pogo/pogo) mouse is a naturally occurring neurological mutant from a Korean wild-type mouse characterized by loss of balance and motor coordination due to dysfunction of the cerebellum. The Pogo mutation is believed to be an allele of P/Q-type calcium channel mutants such as tottering, leaner, and rolling mouse Nagoya. These mutants have been served as mouse models for a group of neurodegenerative diseases. The overall aim of this minireview is to summarize our current understanding of the ataxic Pogo mouse. To address this issue, we first describe the discovery of Pogo mouse and its morphological and behavioral defects. Then, we focus on the abnormal expression of several molecules in the Pogo cerebellum, including tyrosine hydroxylase, glutamate, corticotrophin-releasing factor, and 5-hydroxytryptamine. Much of this review is concerned with the functional implications of these ectopic molecules in the Pogo cerebellum.
“跳跳鼠”（pogo/pogo）是一种源自韩国野生型小鼠的自然发生的神经学突变体，其特征是由于小脑功能障碍而失去平衡和运动协调能力。“跳跳鼠”突变被认为是P/Q型钙通道突变体（如蹒跚鼠、瘦弱鼠和名古屋滚动鼠）的一个等位基因。这些突变体已被用作一组神经退行性疾病的小鼠模型。本小型综述的总体目的是总结我们目前对共济失调型“跳跳鼠”的认识。为解决这个问题，我们首先描述“跳跳鼠”的发现及其形态和行为缺陷。然后，我们重点关注“跳跳鼠”小脑中几种分子的异常表达，包括酪氨酸羟化酶、谷氨酸、促肾上腺皮质激素释放因子和5-羟色胺。本综述的大部分内容都涉及这些异位分子在“跳跳鼠”小脑中的功能意义。
