Kable Julie A, Coles Claire D, Lynch Mary Ellen, Carroll Julie
Department of Pediatrics at Emory University School of Medicine, Atlanta, GA 30324, USA.
Neurotoxicol Teratol. 2009 Jul-Aug;31(4):216-24. doi: 10.1016/j.ntt.2009.02.002. Epub 2009 Feb 27.
Deficits in auditory processing have been posited as one of the underlying neurodevelopmental consequences of maternal smoking during pregnancy that leads to later language and reading deficits. Fast auditory brainstem responses were used to assess differences in the sensory processing of auditory stimuli among infants with varying degrees of prenatal cigarette exposure. Maternal report of consumption of cigarettes and blood samples were collected in the hospital to assess exposure levels and participants were then seen at 6-months. To participate in the study, all infants had to pass the newborn hearing exam or a clinically administered ABR and have no known health problems. After controlling for participant age, maternal smoking during pregnancy was negatively related to latency of auditory brainstem responses. Of several potential covariates, only perinatal complications and maternal alcohol use were also related to latency of the ABR responses and maternal smoking level accounted for significant unique variance after controlling for these factors. These results suggest that the relationship between maternal smoking may lead to disruption in the sensory encoding of auditory stimuli.
听觉处理缺陷被认为是孕期母亲吸烟导致的潜在神经发育后果之一，这种后果会导致后期语言和阅读能力缺陷。快速听觉脑干反应被用于评估不同程度产前香烟暴露婴儿对听觉刺激的感觉处理差异。在医院收集母亲的香烟消费报告和血液样本以评估暴露水平，然后在婴儿6个月时对其进行观察。为了参与该研究，所有婴儿都必须通过新生儿听力检查或临床进行的听觉脑干反应测试，并且没有已知的健康问题。在控制了参与者年龄后，孕期母亲吸烟与听觉脑干反应的潜伏期呈负相关。在几个潜在的协变量中，只有围产期并发症和母亲饮酒也与听觉脑干反应的潜伏期有关，并且在控制这些因素后，母亲吸烟水平占显著的独特方差。这些结果表明，母亲吸烟之间的关系可能导致听觉刺激的感觉编码中断。
