Parker Emily D, Pereira Mark A, Stevens June, Folsom Aaron R
HealthPartners Research Foundation, 8170 33rd Avenue South, Minneapolis, MN 55406-1524, USA.
Am J Epidemiol. 2009 Apr 1;169(7):837-47. doi: 10.1093/aje/kwn395. Epub 2009 Feb 18.
When waist circumference is taken into account, larger hip circumference is associated with reduced risk factors for diabetes and cardiovascular disease. The authors investigated the prospective association of hip circumference with type 2 diabetes and coronary heart disease (CHD) incidence in a biracial cohort of men and women in 4 US communities. A total of 10,767 participants from the Atherosclerosis Risk in Communities (ARIC) study were followed from 1987 to 1998. Hip and waist circumferences and body mass index (BMI) were modeled separately and mutually in association with incident diabetes and CHD by using proportional hazards regression. After adjustment for age, race, sex, and clinical center, hip circumference was positively associated with incident diabetes. However, after further controlling for waist circumference, BMI, and confounding variables, successive quintiles of hip circumference were associated with a statistically significant reduced hazard of incident diabetes (hazard ratios = 1.00, 0.79, 0.60, 0.44, 0.41). Similarly, successive quintiles of hip circumference were associated with a statistically significant reduced hazard of CHD after controlling for waist circumference, BMI, and confounding variables (hazard ratios = 1.00, 0.92, 0.75, 0.63, 0.50). Although excess adiposity is a general risk factor for diabetes and CHD, for a given BMI and waist circumference, greater hip circumference appears to lessen the risk of diabetes and CHD.
当将腰围考虑在内时，较大的臀围与糖尿病和心血管疾病的风险因素降低相关。作者调查了美国4个社区的双种族男性和女性队列中臀围与2型糖尿病和冠心病（CHD）发病率之间的前瞻性关联。1987年至1998年对社区动脉粥样硬化风险（ARIC）研究中的10767名参与者进行了随访。通过比例风险回归分别对臀围、腰围和体重指数（BMI）与糖尿病和冠心病发病情况进行单独建模和相互建模。在对年龄、种族、性别和临床中心进行调整后，臀围与糖尿病发病呈正相关。然而，在进一步控制腰围、BMI和混杂变量后，臀围的连续五分位数与糖尿病发病风险的统计学显著降低相关（风险比=1.00、0.79、0.60、0.44、0.41）。同样，在控制腰围、BMI和混杂变量后，臀围的连续五分位数与冠心病发病风险的统计学显著降低相关（风险比=1.00、0.92、0.75、0.63、0.50）。尽管肥胖是糖尿病和冠心病的一般风险因素，但对于给定的BMI和腰围，较大的臀围似乎会降低糖尿病和冠心病的风险。
