环磷酸腺苷、其丁酰衍生物和丁酸钠对体外恶性滋养层细胞增殖的作用。
The actions of cyclic AMP, its butyryl derivatives and Na butyrate on the proliferation of malignant trophoblast cells in vitro.
作者信息
Barker H, Isles T E
出版信息
Br J Cancer. 1977 Mar;35(3):314-21. doi: 10.1038/bjc.1977.45.
Abstract
Cyclic AMP, and its derivatives N6-monobutyryl cyclic AMP and dibutyryl cyclic AMP, have been found to inhibit the proliferation of trophoblast cells of the BeWo cell line in vitro. Sodium butyrate (1 mM), a possible degradation product of the butyrate derivatives, also inhibited cell proliferation, giving similar growth rates to equimolar dibutyryl cyclic AMP. The inhibition by butyrate was however, not sufficient to account for the action of 1 mM N6-monobutyryl cycli AMP, which, like cyclic AMP, completely inhibited cell proliferation. The potency, specificity and toxicity of the substances were compared. The results suggest different modes of action for cyclic AMP and dibutyryl cyclic AMP.
摘要
环磷酸腺苷（Cyclic AMP）及其衍生物N6 - 单丁酰环磷酸腺苷和二丁酰环磷酸腺苷已被发现可在体外抑制BeWo细胞系滋养层细胞的增殖。丁酸钠（1 mM），丁酸衍生物的一种可能降解产物，也抑制细胞增殖，其生长速率与等摩尔的二丁酰环磷酸腺苷相似。然而，丁酸盐的抑制作用不足以解释1 mM N6 - 单丁酰环磷酸腺苷的作用，后者与环磷酸腺苷一样，完全抑制细胞增殖。对这些物质的效力、特异性和毒性进行了比较。结果表明环磷酸腺苷和二丁酰环磷酸腺苷的作用方式不同。
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