环磷酸腺苷、其丁酰衍生物和丁酸钠对体外恶性滋养层细胞增殖的作用。
The actions of cyclic AMP, its butyryl derivatives and Na butyrate on the proliferation of malignant trophoblast cells in vitro.
作者信息
Barker H, Isles T E
出版信息
Br J Cancer. 1977 Mar;35(3):314-21. doi: 10.1038/bjc.1977.45.
Abstract
Cyclic AMP, and its derivatives N6-monobutyryl cyclic AMP and dibutyryl cyclic AMP, have been found to inhibit the proliferation of trophoblast cells of the BeWo cell line in vitro. Sodium butyrate (1 mM), a possible degradation product of the butyrate derivatives, also inhibited cell proliferation, giving similar growth rates to equimolar dibutyryl cyclic AMP. The inhibition by butyrate was however, not sufficient to account for the action of 1 mM N6-monobutyryl cycli AMP, which, like cyclic AMP, completely inhibited cell proliferation. The potency, specificity and toxicity of the substances were compared. The results suggest different modes of action for cyclic AMP and dibutyryl cyclic AMP.
摘要
环磷酸腺苷（Cyclic AMP）及其衍生物N6 - 单丁酰环磷酸腺苷和二丁酰环磷酸腺苷已被发现可在体外抑制BeWo细胞系滋养层细胞的增殖。丁酸钠（1 mM），丁酸衍生物的一种可能降解产物，也抑制细胞增殖，其生长速率与等摩尔的二丁酰环磷酸腺苷相似。然而，丁酸盐的抑制作用不足以解释1 mM N6 - 单丁酰环磷酸腺苷的作用，后者与环磷酸腺苷一样，完全抑制细胞增殖。对这些物质的效力、特异性和毒性进行了比较。结果表明环磷酸腺苷和二丁酰环磷酸腺苷的作用方式不同。
相似文献
1
The actions of cyclic AMP, its butyryl derivatives and Na butyrate on the proliferation of malignant trophoblast cells in vitro.环磷酸腺苷、其丁酰衍生物和丁酸钠对体外恶性滋养层细胞增殖的作用。
Br J Cancer. 1977 Mar;35(3):314-21. doi: 10.1038/bjc.1977.45.
2
Actions of cyclic AMP, its butyryl derivatives and Na butyrate on the HCG output of malignant trophoblast cells in vitro.环磷酸腺苷、其丁酰衍生物及丁酸钠对体外恶性滋养层细胞人绒毛膜促性腺激素分泌量的作用
Br J Cancer. 1978 Jul;38(1):158-62. doi: 10.1038/bjc.1978.178.
3
Comparison of the effects of forskolin and dibutyryl cyclic AMP in neuroblastoma cells: evidence that some of the actions of dibutyryl cyclic AMP are mediated by butyrate.福司可林与二丁酰环磷腺苷对神经母细胞瘤细胞作用的比较：二丁酰环磷腺苷的某些作用由丁酸盐介导的证据
J Neurochem. 1988 Dec;51(6):1808-18. doi: 10.1111/j.1471-4159.1988.tb01162.x.
4
Further studies on the effect of adenosine cyclic monophosphate derivatives on cell proliferation in the jejunal crypts of rat.
Clin Exp Pharmacol Physiol. 1982 Nov-Dec;9(6):671-4. doi: 10.1111/j.1440-1681.1982.tb00839.x.
5
6
The role of butyrate in the reverse transformation reaction in mammalian cells.
J Cell Physiol. 1978 Jan;94(1):69-75. doi: 10.1002/jcp.1040940109.
7
Regulation of growth and morphological modulation of HeLa65 cells in monolayer culture by dibutyryl cyclic AMP, butyrate and their analogs.
J Cell Physiol. 1975 Dec;86 Suppl 2(3 Pt 2):663-72. doi: 10.1002/jcp.1040860511.
8
Effect of cyclic 3':5'-AMP derivatives prostaglandins and related agents on human chorionic gonadotropin secretion in human malignant trophoblast in culture.
In Vitro. 1977 Jul;13(7):443-9. doi: 10.1007/BF02615105.
9
Cytochalasin B-induced multinucleation of murine sarcoma virus-transformed cells. Inhibition by sodium butyrate.
Exp Cell Res. 1979 Jan;118(1):31-7. doi: 10.1016/0014-4827(79)90580-9.
10
Cyclic-AMP-induced differentiation in neuroblastoma is independent of cell division rate.环磷酸腺苷诱导的神经母细胞瘤分化与细胞分裂速率无关。
Nature. 1978 Nov 9;276(5684):194-5. doi: 10.1038/276194a0.
引用本文的文献
1
Enhancement of human chorionic gonadotrophin production by antimetabolites.抗代谢物对人绒毛膜促性腺激素产生的增强作用。
Br J Cancer. 1982 Jul;46(1):22-9. doi: 10.1038/bjc.1982.160.
2
Cyclic nucleotides and cellular kinetics in normal and abnormal human trophoblastic tissue.
Arch Gynecol. 1981;230(4):335-44. doi: 10.1007/BF02199683.
3
Intracellular cAMP determines the extent of degradation and not the synthesis of collagen by rat hepatocytes.细胞内的环磷酸腺苷（cAMP）决定大鼠肝细胞胶原蛋白的降解程度，而非合成程度。
Mol Cell Biochem. 1992 Jan 15;109(1):89-94. doi: 10.1007/BF00230878.
4
Actions of cyclic AMP, its butyryl derivatives and Na butyrate on the HCG output of malignant trophoblast cells in vitro.环磷酸腺苷、其丁酰衍生物及丁酸钠对体外恶性滋养层细胞人绒毛膜促性腺激素分泌量的作用
Br J Cancer. 1978 Jul;38(1):158-62. doi: 10.1038/bjc.1978.178.
本文引用的文献
1
Regulation of tyrosine hydroxylase activity in cultured mouse neuroblastoma cells: elevation induced by analogs of adenosine 3':5'-cyclic monophosphate.培养的小鼠神经母细胞瘤细胞中酪氨酸羟化酶活性的调节：3':5'-环磷酸腺苷类似物诱导的升高。
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2241-5. doi: 10.1073/pnas.69.8.2241.
2
Independent dibutyryl cyclic adenosine monophosphate stimulation of human chorionic gonadotropin and estrogen secretion by malignant trophoblast cells in vitro.
J Clin Endocrinol Metab. 1974 Nov;39(5):877-81. doi: 10.1210/jcem-39-5-877.
3
Role of cyclic nucleotides in cancer.环核苷酸在癌症中的作用。
Adv Cyclic Nucleotide Res. 1974;4(0):81-116.
4
Divergent action mechanism of cAMP and dibutyryl cAMP on cell proliferation and macromolecular synthesis in HeLa S3 cultures.环磷酸腺苷（cAMP）和二丁酰环磷酸腺苷（dibutyryl cAMP）对HeLa S3培养物中细胞增殖和大分子合成的不同作用机制
Mol Cell Biochem. 1973 Jun 27;1(2):229-39. doi: 10.1007/BF01659332.
5
Pleiotypic control by adenosine 3':5'-cyclic monophosphate: a model for growth control in animal cells.3':5'-环磷酸腺苷的多效性调控：动物细胞生长调控模型
Proc Natl Acad Sci U S A. 1973 May;70(5):1432-6. doi: 10.1073/pnas.70.5.1432.
6
Morphology and growth rate changes in Chinese hamster cells cultured in presence of sodium butyrate.
Exp Cell Res. 1973 Apr;78(2):456-60. doi: 10.1016/0014-4827(73)90091-8.
7
Effect of dibutyryl cyclic AMP on the restoration of contact inhibition in tumor cells and its relationship to cell density and the cell cycle.
Exp Cell Res. 1973 Feb;76(2):390-4. doi: 10.1016/0014-4827(73)90391-1.
8
Catechol-o-methyl-transferase activity in dibutyryl cyclic AMP, prostaglandin and x-ray -induced differentiated neuroblastoma cell culture.二丁酰环磷酸腺苷、前列腺素和X射线诱导的分化神经母细胞瘤细胞培养中的儿茶酚-O-甲基转移酶活性
Exp Cell Res. 1972 Oct;74(2):532-4. doi: 10.1016/0014-4827(72)90412-0.
9
N 6 -monobutyryladenosine 3':5'-mono phosphate as the biologically active derivative of dibutyryladenosine 3':5'-monophosphate in HeLa S3 cells.N6-单丁酰腺苷3':5'-单磷酸作为二丁酰腺苷3':5'-单磷酸在HeLa S3细胞中的生物活性衍生物。
Eur J Biochem. 1972 May;27(1):197-200. doi: 10.1111/j.1432-1033.1972.tb01826.x.
10
Uptake and metabolism of 3',5' -cyclic adenosine monophosphate and N 6 ,O 2' -dibutyryl 3',5' -cyclic adenosine monophosphate in isolated bovine thyroid cells.
Biochim Biophys Acta. 1972 Apr 21;264(2):289-99. doi: 10.1016/0304-4165(72)90293-0.
Zotero 插件