抗代谢物对人绒毛膜促性腺激素产生的增强作用。
Enhancement of human chorionic gonadotrophin production by antimetabolites.
作者信息
Browne P, Bagshawe K D
出版信息
Br J Cancer. 1982 Jul;46(1):22-9. doi: 10.1038/bjc.1982.160.
Abstract
The action of methotrexate, actinomycin D, bleomycin, vincristine and hydroxyurea on the production of human chorionic gonadotrophin (hCG) by a choriocarcinoma cell line (BeWo) has been studied. hCG production per unit of cell protein was increased, and this was a continuing process only halted by cell death. The proportion of hCG-producing cells in the population increased from approximately 5% to a maximum of approximately 40% during incubation with vincristine. A possible explanation for these and related observations is that cytotoxic agents promote the differentiation of cytotrophoblast to syncytium. A similar mechanism could contribute to the unusual sensitivity of choriocarcinoma to cytotoxic agents.
摘要
已研究了甲氨蝶呤、放线菌素D、博来霉素、长春新碱和羟基脲对绒毛膜癌细胞系（BeWo）产生人绒毛膜促性腺激素（hCG）的作用。每单位细胞蛋白的hCG产量增加，且这是一个仅因细胞死亡才停止的持续过程。在与长春新碱孵育期间，群体中产生hCG的细胞比例从约5%增加到最高约40%。对这些及相关观察结果的一种可能解释是，细胞毒性药物促进细胞滋养层向合体细胞的分化。类似机制可能导致绒毛膜癌对细胞毒性药物具有异常敏感性。
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2
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3
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