Department of Radiation Oncology, Celal Bayar University Medical School, Manisa, Turkey.
Med Oncol. 2010 Mar;27(1):108-13. doi: 10.1007/s12032-009-9181-4. Epub 2009 Feb 19.
The relation of anxiety and depression levels with characteristics of coping with the disease and quality of life were evaluated in women under follow-up for breast cancer.
Patients who had presented to the breast cancer polyclinics for follow-up were evaluated. The Beck Depression and the State-Trait Anxiety inventories were used in the evaluation of depression and anxiety levels. In order to evaluate their power to cope with cancer, the patients were questioned for a social support network. EORTC QLQ-C30 and QLQ-BR23 questionnaires were applied for quality of life evaluations.
There were 23 (19%) patients with depression; 3 (2.5%) with grade I anxiety, 94 (77%) grade II, and 23 (19%) grade III anxiety, respectively. Depression and anxiety levels were affected by the following parameters: being unaccompanied by spouse for hospital follow-ups (P < 0.0001); request to get help by a psychologist (P = 0.02); presence of a person to share their problems (P < 0.0001); and using an alternative treatment (P = 0.04). In the quality of life evaluations, difficulty in sleeping, emotional status, fatigue, and body appearance were related with both depression and anxiety (P < 0.05 for all), whereas physical function (P = 0.002), role performance (P = 0.005), cognitive condition (P < 0.0001), social position (P < 0.0001), pain (P < 0.0001), general health (P < 0.0001), treatment methods (P = 0.001), future anxiety (P < 0.0001), and arm symptoms (P = 0.001) were negatively affected in patients with depression.
High depression and anxiety levels in patients under follow-up for breast cancer influence the coping with cancer and quality of life adversely.
评估随访乳腺癌女性的焦虑和抑郁水平与疾病应对特征和生活质量之间的关系。
评估在乳腺癌门诊就诊的患者。采用贝克抑郁量表和状态-特质焦虑量表评估抑郁和焦虑水平。为了评估他们应对癌症的能力，询问患者是否有社会支持网络。采用 EORTC QLQ-C30 和 QLQ-BR23 问卷进行生活质量评估。
23 例（19%）患者患有抑郁症；3 例（2.5%）患者为轻度焦虑，94 例（77%）为中度焦虑，23 例（19%）为重度焦虑。抑郁和焦虑水平受以下参数影响：独自到医院随访（P < 0.0001）；要求心理医生帮助（P = 0.02）；有人分担问题（P < 0.0001）；使用替代疗法（P = 0.04）。在生活质量评估中，睡眠困难、情绪状态、疲劳和身体外观与抑郁和焦虑均相关（P < 0.05），而身体功能（P = 0.002）、角色功能（P = 0.005）、认知状况（P < 0.0001）、社会地位（P < 0.0001）、疼痛（P < 0.0001）、总体健康（P < 0.0001）、治疗方法（P = 0.001）、未来焦虑（P < 0.0001）和手臂症状（P = 0.001）在患有抑郁症的患者中受到负面影响。
乳腺癌随访患者的高抑郁和焦虑水平会对癌症应对和生活质量产生不利影响。
