Mälarsjukhuset, Eskilstuna, Sörmlands läns landsting, Sweden.
Med Oncol. 2010 Mar;27(1):105-7. doi: 10.1007/s12032-009-9180-5. Epub 2009 Feb 19.
In order to examine whether symptoms of iron deficiency anemia are due to the iron deficiency itself or the associated anemia, 34 patients with polycytemia vera (PV) treated with venesectio, who had iron deficiency but normal hemoglobin (Hb) levels, were given a questionnaire covering symptoms of iron deficiency including the international RLS-scale and the Fact-fatigue quality of life scale (QoL). We found a prevalence of pica of 11.7%, mouth paresthesias of 5.8% and rest-less legs 29.6% (RLS "normal" prevalence 10%). Thus, the prevalence of RLS is significantly higher in our population. We also saw a significant difference in QoL between patients with and without RLS (P = 0.015) and QoL correlated with the severity of RLS (R = 0.85). In conclusion, RLS seems to be a frequent and serious problem for PV patients treated with venesectio according to standard guidelines.
为了研究缺铁性贫血的症状是源于缺铁本身还是相关的贫血，我们对 34 名接受静脉放血治疗的真性红细胞增多症（PV）患者进行了研究，这些患者存在铁缺乏但血红蛋白（Hb）水平正常。我们使用涵盖缺铁症状的问卷（包括国际 RLS 量表和 Fact-fatigue 生活质量量表（QoL））对他们进行了调查。我们发现，异食癖的患病率为 11.7%，口腔感觉异常为 5.8%，不安腿为 29.6%（RLS“正常”患病率为 10%）。因此，我们人群中的 RLS 患病率明显更高。我们还发现，有 RLS 和无 RLS 的患者之间的 QoL 存在显著差异（P=0.015），并且 QoL 与 RLS 的严重程度相关（R=0.85）。总之，根据标准指南，静脉放血治疗的 PV 患者中 RLS 似乎是一个常见且严重的问题。
