Department of Internal Medicine, Necmettin Erbakan University, Konya, Turkey.
Division of Rheumatology, Department of Internal Medicine, Necmettin Erbakan University, Konya, Turkey.
Acta Medica (Hradec Kralove). 2021;64(3):137-144. doi: 10.14712/18059694.2021.24.
We aimed to investigate the prevalence of restless legs syndrome (RLS) and sleep disorders in patients with rheumatoid arthritis (RA), and the association of iron deficiency with them.
The study included 72 patients with RA (59 females, 13 males), and 50 healthy control subjects (57 females, 15 males). Assessments were made using the International RLS Rating Scale, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, Fatigue Severity Scale (FSS), Beck anxiety and depression index and the SF-36 quality of life scores.
We found that the frequency of RLS in RA patients was 29.1% and 13.8% in healthy control (p = 0.021). RA patients had 44.4% iron deficiency and 5.5% anemia of chronic disease. We found that 52.3% of patients with iron deficiency had RLS. There was an independent relationship between present of RLS and FSS (Beta [β] = 0.317, p = 0.005) and total iron binding capacity (TIBC) (β = 0.244, p = 0.031). There was an independent relationship between RLS severity score and PSQI (β = 0.264, p = 0.025) and social functionality (β = 0.302, p = 0.009).
The prevalence of iron deficiency is high in RA in the developing countries. Analysis obtained in patients with RA is suggestive of an association between iron deficiency and increased frequency of RLS. The presence of RLS in patients with RA negatively affects sleep quality, psychiatric status, and quality of life of patients with RA. TIBC value may be a predictive marker for early detection of RLS in patients with RA.
本研究旨在调查类风湿关节炎（RA）患者中不安腿综合征（RLS）和睡眠障碍的患病率，以及铁缺乏与它们的关系。
该研究纳入了 72 例 RA 患者（59 名女性，13 名男性）和 50 名健康对照者（57 名女性，15 名男性）。采用国际 RLS 评定量表、匹兹堡睡眠质量指数（PSQI）、Epworth 嗜睡量表、疲劳严重程度量表（FSS）、贝克焦虑和抑郁指数以及 SF-36 生活质量评分进行评估。
我们发现 RA 患者中 RLS 的发生率为 29.1%，健康对照组为 13.8%（p = 0.021）。RA 患者中有 44.4%存在铁缺乏，5.5%存在慢性病性贫血。我们发现 52.3%的铁缺乏患者存在 RLS。RLS 的存在与 FSS（β=0.317，p=0.005）和总铁结合能力（TIBC）（β=0.244，p=0.031）独立相关。RLS 严重程度评分与 PSQI（β=0.264，p=0.025）和社会功能（β=0.302，p=0.009）独立相关。
在发展中国家，RA 患者中缺铁的患病率很高。对 RA 患者的分析表明，铁缺乏与 RLS 发生率增加之间存在关联。RA 患者中 RLS 的存在会对睡眠质量、精神状态和 RA 患者的生活质量产生负面影响。TIBC 值可能是 RA 患者 RLS 早期检测的预测标志物。
