Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
World J Biol Psychiatry. 2009;10(4 Pt 3):772-7. doi: 10.1080/15622970902718782.
Electroconvulsive therapy (ECT) is generally recommended for treating catatonic schizophrenia. Non-catatonic schizophrenia patients also receive ECT. We compared the speed of response to ECT among patients with catatonic and other subtypes of schizophrenia.
Consecutive schizophrenia patients referred for ECT within 3 months of starting antipsychotic treatment were studied (19 with catatonic and 34 with non-catatonic schizophrenia). Nurse's Observation Scale for Inpatient Evaluation (NOSIE-30) and Clinical Global Impression (CGI) were used to rate improvement. Referring psychiatrists stopped ECTs based on clinical impression of improvement. Total number of ECTs was taken as an indirect measure of speed of response. NOSIE-30 scores were compared using repeated measures analysis of variance.
Catatonic schizophrenia patients required significantly fewer ECTs to achieve clinically significant improvement. There was a significant group x occasion effect in NOSIE scores, suggesting faster response to ECT in the catatonia group (F=41.6; P<0.001). Survival analysis suggested that patients with catatonic schizophrenia required significantly fewer ECTs (one less session on an average) to achieve clinical improvement (Log-rank statistic =5.31; P=0.02).
Catatonic schizophrenia responds faster to ECT than non-catatonic schizophrenia. However, the magnitude of the difference is modest.
电抽搐治疗（ECT）通常被推荐用于治疗紧张型精神分裂症。非紧张型精神分裂症患者也接受 ECT。我们比较了紧张型和其他亚型精神分裂症患者对 ECT 的反应速度。
连续接受 ECT 的精神分裂症患者在开始使用抗精神病药物治疗后 3 个月内被研究（19 例为紧张型，34 例为非紧张型）。使用护士观察住院病人评定量表（NOSIE-30）和临床总体印象量表（CGI）来评定改善情况。根据改善的临床印象，转诊精神科医生停止 ECT。ECT 的总数被作为反应速度的间接测量。使用重复测量方差分析比较 NOSIE-30 评分。
紧张型精神分裂症患者需要更少的 ECT 即可达到临床显著改善。NOSIE 评分存在显著的组间 x 时间效应，提示紧张症组对 ECT 的反应更快（F=41.6；P<0.001）。生存分析表明，紧张型精神分裂症患者需要更少的 ECT（平均少一次）即可达到临床改善（对数秩统计=5.31；P=0.02）。
紧张型精神分裂症对 ECT 的反应速度快于非紧张型精神分裂症。然而，差异的幅度不大。
