McKenna F W, Ahmad S
Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Phys Med Biol. 2009 Mar 21;54(6):1593-608. doi: 10.1088/0031-9155/54/6/013. Epub 2009 Feb 19.
Stereotactic body radiation therapy (SBRT) uses high doses of radiation to treat tumors. The cell survival behavior at these high doses is subject to debate. We investigated this high-dose region by fitting a variety of formulas to cell survival data. Each of the formulas is motivated by a discussion of the theory of cell survival. Fourteen cell lines are examined. These are fit to a variety of equations. Among the equations include the traditional single-hit multi-target and linear quadratic as well as recent proposals such as the universal survival curve (USC). The chi(2)/df of each fit is compared to determine the best fit. While no formula is clearly superior for all cell lines, the newer formulas often provide better fits than the single-hit multi-target and linear quadratic. We recommend that the more recent formula discussed herein be used over the linear quadratic in dealing with the high-dose regions dealt with in SBRT.
立体定向体部放射治疗（SBRT）使用高剂量辐射来治疗肿瘤。在这些高剂量下的细胞存活行为存在争议。我们通过将各种公式拟合到细胞存活数据来研究这个高剂量区域。每个公式都基于对细胞存活理论的讨论。研究了14种细胞系。将它们拟合到各种方程。这些方程包括传统的单靶点多靶模型和线性二次模型以及最近提出的通用存活曲线（USC）等。比较每种拟合的卡方/自由度以确定最佳拟合。虽然没有一个公式对所有细胞系都明显优越，但新公式通常比单靶点多靶模型和线性二次模型拟合得更好。我们建议在处理SBRT中的高剂量区域时，使用本文讨论的更新公式而非线性二次模型。
