This study evaluates the safe sex determinants in college students. In the qualitative section, premarital sex, sex with steady girlfriend and religion's impact were highlighted. In the quantitative part, the relations between the religiosity score and past sexual activity, attitude, norms, and self-efficacy with regard to sexual abstinence were investigated. Students who had a higher religious score were significantly more likely to have high self-efficacy in refusing sex, and their attitudes supported their abstinence. Additionally, these students were more likely never to have had a sexual relationship. Findings suggest that greater religious involvement is a protective factor in high-risk sexual behavior.