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Inhibition of DNA topoisomerase II with etoposide induces association of DNA topoisomerase II alpha, DNA topoisomerase II beta, and nucleolin with BCR 2 of the ETO gene.

作者信息

Rubtsov M A, Razin S V, Iarovaia O V

机构信息

Department of Molecular Biology, Faculty of Biology, Moscow State University, Moscow, 119991 Russia.

出版信息

Dokl Biochem Biophys. 2008 Nov-Dec;423:334-6. doi: 10.1134/s1607672908060045.

DOI:10.1134/s1607672908060045
PMID:19230382
Abstract
摘要

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Inhibition of DNA topoisomerase II with etoposide induces association of DNA topoisomerase II alpha, DNA topoisomerase II beta, and nucleolin with BCR 2 of the ETO gene.依托泊苷对DNA拓扑异构酶II的抑制作用可诱导DNA拓扑异构酶IIα、DNA拓扑异构酶IIβ和核仁素与ETO基因的BCR 2发生关联。
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本文引用的文献

1
Repositioning of ETO gene in cells treated with VP-16, an inhibitor of DNA-topoisomerase II.
J Cell Biochem. 2008 May 15;104(2):692-9. doi: 10.1002/jcb.21656.
2
Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.DNA拓扑异构酶II同工酶在化疗和继发性恶性肿瘤中的作用。
Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11014-9. doi: 10.1073/pnas.0704002104. Epub 2007 Jun 19.
3
Chromatin structural elements and chromosomal translocations in leukemia.白血病中的染色质结构元件与染色体易位
DNA Repair (Amst). 2006 Sep 8;5(9-10):1282-97. doi: 10.1016/j.dnarep.2006.05.020. Epub 2006 Aug 7.
4
Assembly of nuclear matrix-bound protein complexes involved in non-homologous end joining is induced by inhibition of DNA topoisomerase II.参与非同源末端连接的核基质结合蛋白复合物的组装是由DNA拓扑异构酶II的抑制所诱导的。
J Cell Physiol. 2006 Jun;207(3):660-7. doi: 10.1002/jcp.20597.
5
Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16).伴有t(11;16)的白血病患者中MLL和CBP基因断裂点的特征分析
Genes Chromosomes Cancer. 2004 Nov;41(3):257-65. doi: 10.1002/gcc.20077.
6
Breakpoint clusters: reason or consequence?
Crit Rev Eukaryot Gene Expr. 2004;14(1-2):65-77.
7
Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.急性髓系白血病（AML）中1型急性髓细胞白血病基因（AML1）/核心结合因子α亚基1（RUNX1）和八分体-2（ETO）的基因组DNA断点，与8号和21号染色体易位（t(8;21)）白血病中的拓扑异构酶II DNA切割及DNA酶I高敏位点聚集在一起。
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3070-5. doi: 10.1073/pnas.042702899. Epub 2002 Feb 26.
8
Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992.DNA拓扑异构酶II抑制剂治疗后伴MLL重排的治疗相关急性淋巴细胞白血病，一个日益严重的问题：两例新病例报告及1992年以来的文献综述
Br J Haematol. 2001 Sep;114(3):539-43. doi: 10.1046/j.1365-2141.2001.03000.x.
9
The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells.正常细胞和emerin突变体细胞细胞核内人类染色体的空间组织。
Hum Mol Genet. 2001 Feb 1;10(3):211-9. doi: 10.1093/hmg/10.3.211.
10
Nucleolin promotes homologous DNA pairing in vitro.核仁素在体外促进同源DNA配对。
Somat Cell Mol Genet. 1998 Sep;24(5):263-72. doi: 10.1023/b:scam.0000007129.98789.1f.