肿瘤坏死因子超家族：共刺激作用与临床应用
TNF superfamily: costimulation and clinical applications.
作者信息
Vinay Dass S, Kwon Byoung S
机构信息
Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.
出版信息
Cell Biol Int. 2009 Apr;33(4):453-65. doi: 10.1016/j.cellbi.2009.02.001. Epub 2009 Feb 20.
Abstract
The molecules concerned with costimulation belong either to the immunoglobulin (Ig) or tumor necrosis factor (TNF) superfamily. The tumor necrosis superfamily comprises molecules capable of providing both costimulation and cell death. In this review we briefly summarize certain TNF superfamily receptor-ligand pairs that are endowed with costimulatory properties and their importance in health and disease.
摘要
参与共刺激的分子要么属于免疫球蛋白（Ig）超家族，要么属于肿瘤坏死因子（TNF）超家族。肿瘤坏死因子超家族包含能够同时提供共刺激和诱导细胞死亡的分子。在本综述中，我们简要总结了某些具有共刺激特性的肿瘤坏死因子超家族受体 - 配体对及其在健康和疾病中的重要性。
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