胰腺癌干细胞：确有其事还是无稽之谈？
Pancreatic cancer stem cells: fact or fiction?
作者信息
Bhagwandin Vikash J, Shay Jerry W
机构信息
University of California, San Francisco, CA 94143-0552, USA.
出版信息
Biochim Biophys Acta. 2009 Apr;1792(4):248-59. doi: 10.1016/j.bbadis.2009.02.007. Epub 2009 Feb 21.
Abstract
The terms cancer-initiating or cancer stem cells have been the subject of great interest in recent years. In this review we will use pancreatic cancer as an overall theme to draw parallels with historical findings to compare to recent reports of stem-like characteristics in pancreatic cancer. We will cover such topics as label-retaining cells (side-population), ABC transporter pumps, telomerase, quiescence, cell surface stem cell markers, and epithelial-mesenchymal transitions. Finally we will integrate the available findings into a pancreatic stem cell model that also includes metastatic disease.
摘要
近年来，癌症起始细胞或癌症干细胞一直是备受关注的主题。在本综述中，我们将以胰腺癌为总体主题，与历史研究结果进行对比，以比较近期关于胰腺癌干细胞样特征的报道。我们将涵盖诸如标记保留细胞（侧群细胞）、ABC转运蛋白泵、端粒酶、静止状态、细胞表面干细胞标志物以及上皮-间质转化等主题。最后，我们将把现有研究结果整合到一个也包括转移性疾病的胰腺干细胞模型中。
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