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一种源自海洋真菌烟曲霉（Aspergillus fumigatus Fres.）的新型gliotoxin类似物。

A new gliotoxin analogue from a marine-derived fungus Aspergillus fumigatus Fres.

作者信息

Zhao Wen Ying, Zhu Tian Jiao, Han Xiao Xian, Fan Guo Tao, Liu Hong Bing, Zhu Wei Ming, Qun Gu Qian

机构信息

Key Laboratory of Marine Drugs, Ministry of Education, Marine Drugs and Food Institute, Ocean University of China, Qingdao, China.

出版信息

Nat Prod Res. 2009;23(3):203-7. doi: 10.1080/14786410600906970.

DOI:10.1080/14786410600906970
PMID:19235019
Abstract

A new gliotoxin analogue (1), as well as four known compounds gliotoxin (2), bisdethiobis (methylthio) gliotoxin (3), bis-N-norgliovictin (4) and didehydrobisdethiobis (methylthio) gliotoxin (5), were isolated from a culture of marine-derived fungus Aspergillus fumigatus Fres. The structure of 1 was determined on the basis of spectroscopic methods. All five compounds were evaluated for the cytotoxic effects on tsFT210 cell line by the SRB method.

摘要

从海洋来源的烟曲霉Fres培养物中分离出一种新的gliotoxin类似物（1）以及四种已知化合物gliotoxin（2）、双去硫双（甲硫基）gliotoxin（3）、双-N-去甲gliovictin（4）和双脱氢双去硫双（甲硫基）gliotoxin（5）。通过光谱方法确定了1的结构。采用SRB法评估了所有五种化合物对tsFT210细胞系的细胞毒性作用。

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