Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657, Japan.
J Nat Prod. 2012 Jan 27;75(1):111-4. doi: 10.1021/np200740e. Epub 2011 Dec 12.
Seven gliotoxin-related compounds were isolated from the fungus Penicillium sp. strain JMF034, obtained from deep sea sediments of Suruga Bay, Japan. These included two new metabolites, bis(dethio)-10a-methylthio-3a-deoxy-3,3a-didehydrogliotoxin (1) and 6-deoxy-5a,6-didehydrogliotoxin (2), and five known metabolites (3-7). The structures of the new compounds were elucidated by analysis of spectroscopic data and the application of the modified Mosher's analysis. All of the compounds exhibited cytotoxic activity, whereas compounds containing a disulfide bond showed potent inhibitory activity against histone methyltransferase (HMT) G9a. None of them inhibited HMT SET7/9.
从日本骏海湾深海沉积物中分离得到的青霉属菌株 JMF034 中分离得到 7 种与Gliotoxin 相关的化合物。其中包括两种新的代谢物，双（脱巯基）-10a-甲基硫代-3a-去氧-3,3a-二氢Gliotoxin（1）和 6-脱氧-5a,6-二氢Gliotoxin（2），以及五种已知的代谢物（3-7）。通过分析光谱数据和应用改良的 Mosher 分析，确定了新化合物的结构。所有化合物均表现出细胞毒性，而含有二硫键的化合物对组蛋白甲基转移酶（HMT）G9a 具有很强的抑制活性。它们均没有抑制 HMT SET7/9。
