Koopman-Kimenai P M, Vree T B, Hasenbos M A, Weber E W, Verweij-Van Wissen C P, Booij L H
Department of Clinical Pharmacy, Academic Hospital, Nijmegen Sint Radboud, The Netherlands.
Pharm Weekbl Sci. 1991 Jun 21;13(3):142-7. doi: 10.1007/BF01981532.
In ten patients who received an epidural injection of 15 mg of nicomorphine, the compound was relatively slowly released from the epidural space and was found in plasma for approximately 1.5 h. Nicomorphine is relatively slowly metabolized into 6-nicotinoylmorphine and morphine. The rate of release is patient-dependent. The relative AUC values are 15.3% for nicomorphine, 23.9% for 6-nicotinoylmorphine and 60.8% for morphine. The mean clinical effect lasts for 18.2 +/- 10.1 h.
