Pleteneva E A, Shaburova O V, Krylov V N
Genetika. 2009 Jan;45(1):43-9.
In recent years, a revival of interest to study of bacteriophages has been observed. Bacteriophages and phage-coded products can be used as antibiotics in the treatment of some human and animal infections caused by antibiotic-resistant bacterial strains. Bacteriophages may serve as an excellent method for monitoring anthropogenic changes in bacterial communities, which are connected with the contamination by industrial sewages or infection of water reservoirs with pathogenic bacteria. Technical applicability of bacteriophages may be successful for combating bacterial biofilms, for example, in pipelines. And finally, comparative basic and systemic genomic studies of bacteriophages belonging to various bacterial species are decisive in understanding and assessing their role in the joint evolution (coevolution) with host bacteria; particularly, this research is important for elucidating mechanisms of phage participation in the horizontal exchange of genetic modules. Possibly, these studies may be useful for the prediction of not only the direction of coevolution of certain bacterial species and their phages but also the time of novel pathogenic bacteria origination.
近年来，人们对噬菌体研究的兴趣再度兴起。噬菌体和噬菌体编码产物可作为抗生素，用于治疗由耐抗生素细菌菌株引起的一些人类和动物感染。噬菌体可作为监测细菌群落人为变化的绝佳方法，这些变化与工业污水污染或病原菌感染水库有关。噬菌体的技术适用性在对抗细菌生物膜方面可能会取得成功，例如在管道中。最后，对属于不同细菌物种的噬菌体进行比较基础和系统的基因组研究，对于理解和评估它们在与宿主细菌的共同进化（协同进化）中的作用具有决定性意义；特别是，这项研究对于阐明噬菌体参与遗传模块水平交换的机制很重要。这些研究可能不仅有助于预测某些细菌物种及其噬菌体的协同进化方向，还能预测新病原菌出现的时间。
