针对铜绿假单胞菌感染进行安全噬菌体治疗的噬菌体选择及条件
Selection of phages and conditions for the safe phage therapy against Pseudomonas aeruginosa infections.
作者信息
Krylov Victor, Shaburova Olga, Pleteneva Elena, Krylov Sergey, Kaplan Alla, Burkaltseva Maria, Polygach Olga, Chesnokova Elena
机构信息
I.I. Mechnikov Research Institute for Vaccines & Sera, RAMS, Moscow, 105064, Russian,
出版信息
Virol Sin. 2015 Feb;30(1):33-44. doi: 10.1007/s12250-014-3546-3. Epub 2015 Feb 5.
Abstract
The emergence of multidrug-resistant bacterial pathogens forced us to consider the phage therapy as one of the possible alternative approaches to treatment. The purpose of this paper is to consider the conditions for the safe, long-term use of phage therapy against various infections caused by Pseudomonas aeruginosa. We describe the selection of the most suitable phages, their most effective combinations and some approaches for the rapid recognition of phages unsuitable for use in therapy. The benefits and disadvantages of the various different approaches to the preparation of phage mixtures are considered, together with the specific conditions that are required for the safe application of phage therapy in general hospitals and the possibilities for the development of personalized phage therapy.
摘要
多重耐药性细菌病原体的出现迫使我们将噬菌体疗法视为一种可能的替代治疗方法。本文的目的是探讨安全、长期使用噬菌体疗法治疗由铜绿假单胞菌引起的各种感染的条件。我们描述了最合适噬菌体的选择、它们最有效的组合以及一些快速识别不适合用于治疗的噬菌体的方法。考虑了制备噬菌体混合物的各种不同方法的优缺点，以及在综合医院安全应用噬菌体疗法所需的具体条件和个性化噬菌体疗法发展的可能性。
相似文献
1
Selection of phages and conditions for the safe phage therapy against Pseudomonas aeruginosa infections.针对铜绿假单胞菌感染进行安全噬菌体治疗的噬菌体选择及条件
Virol Sin. 2015 Feb;30(1):33-44. doi: 10.1007/s12250-014-3546-3. Epub 2015 Feb 5.
2
Bacteriophages of Pseudomonas aeruginosa: long-term prospects for use in phage therapy.铜绿假单胞菌噬菌体：噬菌体疗法的长期前景。
Adv Virus Res. 2014;88:227-78. doi: 10.1016/B978-0-12-800098-4.00005-2.
3
Characterization of JG024, a pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions.在模拟感染条件下对一株假单胞菌 PB1 样广宿主范围噬菌体 JG024 的特性进行研究。
BMC Microbiol. 2010 Nov 26;10:301. doi: 10.1186/1471-2180-10-301.
4
Optimizing bacteriophage treatment of resistant .优化噬菌体治疗耐药菌。
mSphere. 2024 Jul 30;9(7):e0070723. doi: 10.1128/msphere.00707-23. Epub 2024 Jun 27.
5
Phage Therapy Is Effective in a Mouse Model of Bacterial Equine Keratitis.噬菌体疗法对细菌性马角膜炎小鼠模型有效。
Appl Environ Microbiol. 2016 Aug 15;82(17):5332-9. doi: 10.1128/AEM.01166-16. Print 2016 Sep 1.
6
Bacteriophage PEV20 and Ciprofloxacin Combination Treatment Enhances Removal of Pseudomonas aeruginosa Biofilm Isolated from Cystic Fibrosis and Wound Patients.噬菌体 PEV20 与环丙沙星联合治疗增强了从囊性纤维化和创伤患者中分离的铜绿假单胞菌生物膜的清除。
AAPS J. 2019 Apr 4;21(3):49. doi: 10.1208/s12248-019-0315-0.
7
Design of a Broad-Range Bacteriophage Cocktail That Reduces Pseudomonas aeruginosa Biofilms and Treats Acute Infections in Two Animal Models.设计一种广谱噬菌体鸡尾酒，减少铜绿假单胞菌生物膜并在两种动物模型中治疗急性感染。
Antimicrob Agents Chemother. 2018 May 25;62(6). doi: 10.1128/AAC.02573-17. Print 2018 Jun.
8
Phage Therapy: a Step Forward in the Treatment of Pseudomonas aeruginosa Infections.噬菌体疗法：治疗铜绿假单胞菌感染的一项进展。
J Virol. 2015 Aug;89(15):7449-56. doi: 10.1128/JVI.00385-15. Epub 2015 May 13.
9
Bacteriophages φMR299-2 and φNH-4 can eliminate Pseudomonas aeruginosa in the murine lung and on cystic fibrosis lung airway cells.噬菌体 φMR299-2 和 φNH-4 可以消除肺部的铜绿假单胞菌和囊性纤维化肺气道细胞中的铜绿假单胞菌。
mBio. 2012 Mar 6;3(2):e00029-12. doi: 10.1128/mBio.00029-12. Print 2012.
10
Characterization of five newly isolated bacteriophages active against Pseudomonas aeruginosa clinical strains.对五种新分离出的、对铜绿假单胞菌临床菌株具有活性的噬菌体的特性研究。
Folia Microbiol (Praha). 2015 Jan;60(1):7-14. doi: 10.1007/s12223-014-0333-3. Epub 2014 Jul 4.
引用本文的文献
1
In Vitro Interactions Between Bacteriophages and Antibacterial Agents of Various Classes Against Multidrug-Resistant Metallo-β-Lactamase-Producing Clinical Isolates.噬菌体与各类抗菌剂对产多重耐药金属β-内酰胺酶临床分离株的体外相互作用
Pharmaceuticals (Basel). 2025 Feb 27;18(3):343. doi: 10.3390/ph18030343.
2
New Bacteriophage Phage Ka2 from a Tributary Stream of Lake Baikal.来自贝加尔湖一条支流的新型噬菌体——噬菌体Ka2
Viruses. 2025 Jan 29;17(2):189. doi: 10.3390/v17020189.
3
Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages.噬菌体 ΦKZ 的衣壳结构为巨型噬菌体的组装和稳定提供了线索。
Nat Commun. 2024 Aug 2;15(1):6551. doi: 10.1038/s41467-024-50811-1.
4
Bacteriophage Production in Compliance with Regulatory Requirements.符合监管要求的噬菌体生产。
Methods Mol Biol. 2024;2734:89-115. doi: 10.1007/978-1-0716-3523-0_6.
5
Isolation of a bacteriophage targeting Pseudomonas aeruginosa and exhibits a promising in vivo efficacy.分离出一种靶向铜绿假单胞菌的噬菌体，并在体内显示出有前景的疗效。
AMB Express. 2023 Jul 26;13(1):79. doi: 10.1186/s13568-023-01582-3.
6
Phage Revolution Against Multidrug-Resistant Clinical Pathogens in Southeast Asia.东南亚针对多重耐药临床病原体的噬菌体革命
Front Microbiol. 2022 Jan 27;13:820572. doi: 10.3389/fmicb.2022.820572. eCollection 2022.
7
Black box of phage-bacterium interactions: exploring alternative phage infection strategies.噬菌体-细菌相互作用的黑箱：探索替代噬菌体感染策略。
Open Biol. 2021 Sep;11(9):210188. doi: 10.1098/rsob.210188. Epub 2021 Sep 15.
8
Phage phiKZ-The First of Giants.噬菌体 phiKZ——巨无霸的先驱。
Viruses. 2021 Jan 20;13(2):149. doi: 10.3390/v13020149.
9
vB_PaeM_MIJ3, a Novel Jumbo Phage Infecting , Possesses Unusual Genomic Features.vB_PaeM_MIJ3，一种新型的巨型噬菌体，具有不寻常的基因组特征。
Front Microbiol. 2019 Nov 28;10:2772. doi: 10.3389/fmicb.2019.02772. eCollection 2019.
10
Use of a Primary Epithelial Cell Screening Tool to Investigate Phage Therapy in Cystic Fibrosis.使用原代表皮细胞筛选工具研究囊性纤维化中的噬菌体疗法。
Front Pharmacol. 2018 Nov 28;9:1330. doi: 10.3389/fphar.2018.01330. eCollection 2018.
本文引用的文献
1
Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa.铜绿假单胞菌的两种巨型类phiKZ噬菌体EL和Lin68中的基因组包装
Virology. 2014 Nov;468-470:472-478. doi: 10.1016/j.virol.2014.09.002. Epub 2014 Sep 22.
2
Development of giant bacteriophage ϕKZ is independent of the host transcription apparatus.巨型噬菌体ϕKZ的发育不依赖于宿主转录装置。
J Virol. 2014 Sep;88(18):10501-10. doi: 10.1128/JVI.01347-14. Epub 2014 Jun 25.
3
Art-175 is a highly efficient antibacterial against multidrug-resistant strains and persisters of Pseudomonas aeruginosa.Art-175是一种对铜绿假单胞菌的多重耐药菌株和持留菌具有高效抗菌活性的物质。
Antimicrob Agents Chemother. 2014 Jul;58(7):3774-84. doi: 10.1128/AAC.02668-14. Epub 2014 Apr 21.
4
UFV-P2 as a member of the Luz24likevirus genus: a new overview on comparative functional genome analyses of the LUZ24-like phages.UFV-P2 作为 Luz24likevirus 属的一个成员：对 Luz24 样噬菌体的比较功能基因组分析的新概述。
BMC Genomics. 2014 Jan 3;15:7. doi: 10.1186/1471-2164-15-7.
5
Predicting in vivo efficacy of therapeutic bacteriophages used to treat pulmonary infections.预测用于治疗肺部感染的治疗性噬菌体的体内疗效。
Antimicrob Agents Chemother. 2013 Dec;57(12):5961-8. doi: 10.1128/AAC.01596-13. Epub 2013 Sep 16.
6
Safety analysis of a Russian phage cocktail: from metagenomic analysis to oral application in healthy human subjects.俄罗斯噬菌体鸡尾酒的安全性分析：从宏基因组分析到健康人体的口服应用。
Virology. 2013 Sep 1;443(2):187-96. doi: 10.1016/j.virol.2013.05.022. Epub 2013 Jun 10.
7
Genomic and proteomic analyses of the terminally redundant genome of the Pseudomonas aeruginosa phage PaP1: establishment of genus PaP1-like phages.对铜绿假单胞菌噬菌体 PaP1 末端冗余基因组的基因组和蛋白质组分析：PaP1 样噬菌体属的建立。
PLoS One. 2013 May 13;8(5):e62933. doi: 10.1371/journal.pone.0062933. Print 2013.
8
Importance of prophages to evolution and virulence of bacterial pathogens.原噬菌体对细菌病原体进化和毒力的重要性。
Virulence. 2013 Jul 1;4(5):354-65. doi: 10.4161/viru.24498. Epub 2013 Apr 23.
9
A genetic approach to the development of new therapeutic phages to fight pseudomonas aeruginosa in wound infections.利用遗传方法开发新的治疗性噬菌体来对抗伤口感染中的铜绿假单胞菌。
Viruses. 2012 Dec 21;5(1):15-53. doi: 10.3390/v5010015.
10
Genomic analysis of Pseudomonas putida phage tf with localized single-strand DNA interruptions.具有局部单链 DNA 中断的恶臭假单胞菌噬菌体 tf 的基因组分析。
PLoS One. 2012;7(12):e51163. doi: 10.1371/journal.pone.0051163. Epub 2012 Dec 7.
Zotero 插件