Hano Takuzo, Kasano Miki, Tomari Hiromi, Iwane Naomi
Wakayama Medical University, Postgraduate School of Medicine, Medical Education and Population-based Medicine, Wakayama, Japan.
Adv Exp Med Biol. 2009;643:57-63. doi: 10.1007/978-0-387-75681-3_6.
To investigate the effect of taurine on the sympathetic nervous system, I observed pressor responses of perfused mesenteric arteries by electrical stimulation and baro-reflex sensitivity of spontaneously hypertensive rats (SHR/Izm) and control Wistar-Kyoto rats (WKY/Izm) treated with taurine. Taurine added to the perfusate suppressed norepinephrine (NE) overflow and the pressor response mediated by electrical stimulation of isolated perfused mesenteric arteries. Taurine showed a greater suppressive effect on NE overflow and the pressor response mediated by electrical stimulation in SHR/Izm rats than in WKY/Izm rats. Increment of renal sympathetic nerve activity induced by jet-air stress was suppressed in SHR/Izm rats treated with 3% taurine. The arterial baro-reflex sensitivity was more sensitive in SHR/Izm rats treated with taurine than in those exposed to no taurine. These data suggest that taurine lowers blood pressure directly via the suppression of NE release from the peripheral sympathetic nerve and the improvement of impaired baro-reflex sensitivity.
为研究牛磺酸对交感神经系统的作用，我观察了用牛磺酸处理的自发性高血压大鼠（SHR/Izm）和对照Wistar-Kyoto大鼠（WKY/Izm）的灌注肠系膜动脉对电刺激的升压反应以及压力反射敏感性。添加到灌注液中的牛磺酸抑制了去甲肾上腺素（NE）溢出以及由电刺激离体灌注肠系膜动脉介导的升压反应。与WKY/Izm大鼠相比，牛磺酸对SHR/Izm大鼠的NE溢出和由电刺激介导的升压反应具有更大的抑制作用。在用3%牛磺酸处理的SHR/Izm大鼠中，由喷气应激诱导的肾交感神经活动增加受到抑制。在用牛磺酸处理的SHR/Izm大鼠中，动脉压力反射敏感性比未用牛磺酸处理的大鼠更敏感。这些数据表明，牛磺酸通过抑制外周交感神经释放NE和改善受损的压力反射敏感性直接降低血压。
