Choi Mi-Ja, DiMarco Nancy M
Department of Food and Nutrition, Keimyung University, Daegu, Korea.
Adv Exp Med Biol. 2009;643:341-9. doi: 10.1007/978-0-387-75681-3_35.
This study was performed to evaluate the effect of a diet rich in taurine (2.0 g/100 g) on bone metabolism in ovariectomized (OVX) rats. All rats were fed deionized water during the experimental period. Bone mineral density (BMD) and bone mineral content (BMC) of spine and femur were measured. Serum and urinary calcium and phosphorus content were determined. The levels serum osteocalcin and alkaline phosphatase (ALP) were used to assess bone formation. The rate of bone resorption was measured by the deoxypyridinoline (DPD) crosslink immunoassay and corrected for creatinine. Urinary Ca and P excretion, serum osteocalcin content, and the crosslink value were not significantly different between the Sham groups. The taurine supplemented, Sham group had higher spinal and femur BMC than those of the untreated control group, but the difference was not statistically significant. However, the taurine supplemented, Sham group had significantly higher spine and femur BMC per weight than those of the untreated control group. Within the OVX group, the taurine supplemented group had a lower crosslink value than the casein group. The taurine supplemented, OVX group had higher femur bone mineral content per weight than those of the control, OVX group, but the difference was not statistically significant. A study examining the long-term effect of taurine supplementation in humans is warranted.
本研究旨在评估富含牛磺酸（2.0克/100克）的饮食对去卵巢（OVX）大鼠骨代谢的影响。在实验期间，所有大鼠均饮用去离子水。测量了脊柱和股骨的骨密度（BMD）和骨矿物质含量（BMC）。测定了血清和尿液中的钙和磷含量。血清骨钙素和碱性磷酸酶（ALP）水平用于评估骨形成。通过脱氧吡啶啉（DPD）交联免疫测定法测量骨吸收速率，并对肌酐进行校正。假手术组之间的尿钙和磷排泄、血清骨钙素含量以及交联值无显著差异。补充牛磺酸的假手术组的脊柱和股骨BMC高于未处理的对照组，但差异无统计学意义。然而，补充牛磺酸的假手术组每重量的脊柱和股骨BMC显著高于未处理的对照组。在OVX组中，补充牛磺酸的组的交联值低于酪蛋白组。补充牛磺酸的OVX组每重量的股骨骨矿物质含量高于对照组OVX组，但差异无统计学意义。有必要开展一项研究，考察补充牛磺酸对人类的长期影响。
