Choi Mi-Ja, Chang Kyung Ja
Department of Food and Nutrition, Keimyung University, Korea.
Adv Exp Med Biol. 2009;643:389-95. doi: 10.1007/978-0-387-75681-3_40.
The purpose of this study was to investigate the effect of dietary taurine supplementation on plasma and liver lipid content in ovariectomized (OVX) rats. Forty female Sprague-Dawley rats were divided into two groups, one that was OVX and the other sham operated (Sham). They were further divided into either control or taurine supplemented dietary (2.0 g/100 g diet) subgroups. Plasma lipids (Total cholesterol, HDL-cholesterol, and Triglycerides) and liver lipids were determined by using commercial kits (Wako Pure Chemical, Osaka). LDL-cholsterol content was estimated by the equation of Fridewald et al (1972). There were no significant differences in body weight gain and food intake between the OVX or controls rats that were either control or taurine fed, but body weight gain was higher in the OVX groups. Food intake and the food efficiency ratio were not significantly different between the dietary subgroups. The concentrations of plasma total cholesterol and triglycerides were lower in the taurine, OVX group while the HDL-cholesterol and the LDL-cholesterol levels were not reduced in the two taurine fed subgroups. There were no significant differences in liver cholesterol and triglyceride content between the control, OVX and the taurine, OVX rats. There were no significant differences in the atherogenic index between control, OVX and taurine, OVX groups. These results confirmed that taurine exerts some beneficial effects on hypercholesterolemia and hypertriglyceridemia of the OVX rats.
本研究的目的是探讨补充膳食牛磺酸对去卵巢（OVX）大鼠血浆和肝脏脂质含量的影响。40只雌性Sprague-Dawley大鼠被分为两组，一组为去卵巢组，另一组为假手术组（Sham）。它们又进一步分为对照组或补充牛磺酸膳食（2.0 g/100 g饲料）亚组。血浆脂质（总胆固醇、高密度脂蛋白胆固醇和甘油三酯）和肝脏脂质通过使用商用试剂盒（和光纯药株式会社，大阪）进行测定。低密度脂蛋白胆固醇含量根据Fridewald等人（1972年）的公式估算。在对照组或补充牛磺酸的去卵巢大鼠与对照组大鼠之间，体重增加和食物摄入量没有显著差异，但去卵巢组的体重增加更高。膳食亚组之间的食物摄入量和食物效率比没有显著差异。补充牛磺酸的去卵巢组血浆总胆固醇和甘油三酯浓度较低，而在两个补充牛磺酸的亚组中，高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平没有降低。对照组、去卵巢组和补充牛磺酸的去卵巢大鼠之间肝脏胆固醇和甘油三酯含量没有显著差异。对照组、去卵巢组和补充牛磺酸的去卵巢组之间的动脉粥样硬化指数没有显著差异。这些结果证实，牛磺酸对去卵巢大鼠的高胆固醇血症和高甘油三酯血症有一些有益作用。
