登革热和登革出血热中的一氧化氮：是必需的还是有害的？
Nitric oxide in dengue and dengue haemorrhagic fever: necessity or nuisance?
作者信息
Chaturvedi Umesh C, Nagar Rachna
机构信息
Department of Microbiology, CSM Medical University, Lucknow, India.
出版信息
FEMS Immunol Med Microbiol. 2009 Jun;56(1):9-24. doi: 10.1111/j.1574-695X.2009.00544.x. Epub 2009 Feb 23.
Abstract
Advances in free radical research show that reactive oxygen and nitrogen oxide species, for example superoxide, nitric oxide (NO) and peroxynitrite, play an important role in the pathogenesis of different viral infections, including dengue virus. The pathogenic mechanism of dengue haemorrhagic fever (DHF) is complicated and is not clearly understood. The hallmarks of the dengue disease, the antibody-dependent enhancement, the shift from T-helper type 1 (Th1) to Th2 cytokine response and the cytokine tsunami resulting in vascular leakage can now be explained much better with the knowledge gained about NO and peroxynitrite. This paper makes an effort to present a synthesis of the current opinions to explain the pathogenesis of DHF/shock syndrome with NO on centre stage.
摘要
自由基研究的进展表明，活性氧和氮氧化物，如超氧化物、一氧化氮（NO）和过氧亚硝酸盐，在包括登革热病毒在内的不同病毒感染的发病机制中起重要作用。登革出血热（DHF）的致病机制复杂，目前尚不清楚。现在，利用关于NO和过氧亚硝酸盐的知识，可以更好地解释登革热疾病的特征、抗体依赖性增强、从1型辅助性T细胞（Th1）向Th2细胞因子反应的转变以及导致血管渗漏的细胞因子风暴。本文致力于综合当前观点，以NO为核心来解释DHF/休克综合征的发病机制。
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