Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.
School of Life Science, Tsinghua University, Beijing, 100084, China.
Virol Sin. 2017 Feb;32(1):16-22. doi: 10.1007/s12250-016-3855-9. Epub 2016 Nov 14.
Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome (DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses. This review summarizes the current progress of studies on DHF pathogenesis, which may provide important information for achieving effective control of dengue in the future.
登革病毒（DENV）属于黄病毒科，是一种通过蚊虫传播的病毒。有 4 种血清型的 DENV 可引起人类疾病，通过蚊虫媒介传播。DENV 感染导致广泛的临床症状，从轻微发热到登革出血热（DHF），后者可进展为登革休克综合征（DSS）和死亡。在过去的半个世纪中，研究人员一直在不懈努力，以了解 DHF 的发病机制。DHF 可能由多种因素引起，如病毒特异性抗体、病毒抗原和宿主免疫反应。本综述总结了 DHF 发病机制的研究进展，这可能为未来实现登革热的有效控制提供重要信息。
