Oura Hajimu, Iino Masato, Nakazawa Yosuke, Tajima Masahiro, Ideta Ritsuro, Nakaya Yutaka, Arase Seiji, Kishimoto Jiro
Department of Dermatology, School of Medicine, University of Tokushima, Tokushima, Japan.
J Dermatol. 2008 Dec;35(12):763-7. doi: 10.1111/j.1346-8138.2008.00564.x.
Adenosine upregulates the expression of vascular endothelial growth factor and fibroblast growth factor-7 in cultured dermal papilla cells. It has been shown that, in Japanese men, adenosine improves androgenetic alopecia due to the thickening of thin hair due to hair follicle miniaturization. To investigate the efficacy and safety of adenosine treatment to improve hair loss in women, 30 Japanese women with female pattern hair loss were recruited for this double-blind, randomized, placebo-controlled study. Volunteers used either 0.75% adenosine lotion or a placebo lotion topically twice daily for 12 months. Efficacy was evaluated by dermatologists and by investigators and in phototrichograms. As a result, adenosine was significantly superior to the placebo according to assessments by dermatologists and investigators and by self-assessments. Adenosine significantly increased the anagen hair growth rate and the thick hair rate. No side-effects were encountered during the trial. Adenosine improved hair loss in Japanese women by stimulating hair growth and by thickening hair shafts. Adenosine is useful for treating female pattern hair loss in women as well as androgenetic alopecia in men.
腺苷可上调培养的毛乳头细胞中血管内皮生长因子和成纤维细胞生长因子-7的表达。研究表明，在日本男性中，腺苷可改善雄激素性脱发，这是由于毛囊小型化导致的细发变粗。为了研究腺苷治疗女性脱发的疗效和安全性，招募了30名患有女性型脱发的日本女性参与这项双盲、随机、安慰剂对照研究。志愿者每天两次外用0.75%腺苷洗剂或安慰剂洗剂，持续12个月。由皮肤科医生、研究人员通过毛发照片评估疗效。结果显示，根据皮肤科医生、研究人员的评估以及自我评估，腺苷显著优于安慰剂。腺苷显著提高了生长期头发生长率和粗发率。试验期间未出现副作用。腺苷通过刺激毛发生长和使毛干变粗来改善日本女性的脱发情况。腺苷对治疗女性的女性型脱发以及男性的雄激素性脱发均有效。
