Watanabe Y, Nagashima T, Hanzawa N, Ishino A, Nakazawa Y, Ogo M, Iwabuchi T, Tajima M
Watanabe Dermatological Clinic, Tokyo, Japan.
Shinjuku Biru Clinic, Tokyo, Japan.
Int J Cosmet Sci. 2015 Dec;37(6):579-87. doi: 10.1111/ics.12235. Epub 2015 May 18.
Hair thickness is more important than hair density in the appearance of baldness in male with androgenetic alopecia (AGA). Adenosine improves hair loss by stimulating hair growth and by thickening hair shafts in women. The objective of this study was to evaluate the hair growth efficacy and safety of topical adenosine in men with AGA.
A lotion containing either adenosine or niacinamide was administered to the scalps of 102 Japanese men twice daily for 6 months in a double-blind, randomized study. Efficacy was evaluated by dermatologists who assessed the quality of the hair and by calculating the percentages of vellus-like and thick hairs among the vertex hairs, as well as hair density.
Adenosine was significantly (P < 0.05) superior to niacinamide in terms of global improvement of AGA, increase in the percentage of thick hairs (at least 60 μm) and self-assessment of hair thickness by the study participants. No causal adverse event due to the adenosine lotion was observed.
These data indicate that adenosine increases thick hair ratio in Japanese men with AGA, and this compound is useful for the improvement of AGA.
在雄激素性脱发（AGA）男性秃发外观中，头发粗细比头发密度更重要。腺苷通过刺激头发生长和增厚女性发杆来改善脱发。本研究的目的是评估局部应用腺苷对AGA男性的生发疗效和安全性。
在一项双盲、随机研究中，将含有腺苷或烟酰胺的洗剂每日两次涂抹于102名日本男性的头皮上，持续6个月。由皮肤科医生通过评估头发质量、计算头顶毛发中毳毛样毛发和粗毛发的百分比以及头发密度来评估疗效。
在AGA的整体改善、粗毛发（至少60μm）百分比增加以及研究参与者对头发粗细的自我评估方面，腺苷显著（P<0.05）优于烟酰胺。未观察到因腺苷洗剂引起的因果性不良事件。
这些数据表明，腺苷可增加AGA日本男性的粗发比例，该化合物对改善AGA有效。
