Tuncbag Nurcan, Kar Gozde, Keskin Ozlem, Gursoy Attila, Nussinov Ruth
Computational Sciences and Engineering Program at Koc University, Istanbul, Turkey.
Brief Bioinform. 2009 May;10(3):217-32. doi: 10.1093/bib/bbp001. Epub 2009 Feb 24.
The unanimous agreement that cellular processes are (largely) governed by interactions between proteins has led to enormous community efforts culminating in overwhelming information relating to these proteins; to the regulation of their interactions, to the way in which they interact and to the function which is determined by these interactions. These data have been organized in databases and servers. However, to make these really useful, it is essential not only to be aware of these, but in particular to have a working knowledge of which tools to use for a given problem; what are the tool advantages and drawbacks; and no less important how to combine these for a particular goal since usually it is not one tool, but some combination of tool-modules that is needed. This is the goal of this review.
细胞过程(在很大程度上)由蛋白质之间的相互作用所支配,这一共识促使整个科学界付出了巨大努力,最终产生了与这些蛋白质相关的海量信息,包括它们相互作用的调控、相互作用的方式以及由这些相互作用所决定的功能。这些数据已被整理到数据库和服务器中。然而,要使这些数据真正发挥作用,不仅要了解它们,更重要的是要切实掌握针对特定问题应使用哪些工具;这些工具的优缺点是什么;同样重要的是,如何为实现特定目标而将这些工具结合起来,因为通常需要的不是一种工具,而是工具模块的某种组合。这就是本综述的目标。