Riley Robert, Lee Christopher, Sabatti Chiara, Eisenberg David
Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA.
Genome Biol. 2005;6(10):R89. doi: 10.1186/gb-2005-6-10-r89. Epub 2005 Sep 19.
We describe domain pair exclusion analysis (DPEA), a method for inferring domain interactions from databases of interacting proteins. DPEA features a log odds score, Eij, reflecting confidence that domains i and j interact. We analyzed 177,233 potential domain interactions underlying 26,032 protein interactions. In total, 3,005 high-confidence domain interactions were inferred, and were evaluated using known domain interactions in the Protein Data Bank. DPEA may prove useful in guiding experiment-based discovery of previously unrecognized domain interactions.
我们描述了结构域对排除分析（DPEA），这是一种从相互作用蛋白数据库推断结构域相互作用的方法。DPEA具有对数优势分数Eij，反映结构域i和j相互作用的可信度。我们分析了26,032种蛋白质相互作用背后的177,233种潜在结构域相互作用。总共推断出3,005种高可信度的结构域相互作用，并使用蛋白质数据库中的已知结构域相互作用进行了评估。DPEA可能有助于指导基于实验发现以前未识别的结构域相互作用。
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