Miao Mingsan, Yan Xiaoli, Guo Lin, Li Pengfei
Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China.
Saudi J Biol Sci. 2017 Jan;24(1):139-148. doi: 10.1016/j.sjbs.2016.09.009. Epub 2016 Sep 10.
To observe the effect of cynomorium total flavone on the depression model of perimenopausal rat and to analyze the action characteristics of cynomorium total flavone on depression of rat with perimenopausal syndrome.
Duplicate the model of rat with perimenopausal depression based on the combined method of incomplete castration and chronic stimulation, and keep drug administration for 35d. And then measure related behavior indicators and the change of biochemical index level in serum and brains; measure the estrogen/androgen receptor (ER/AR) in related tissues and the ERmRNA expression in hypothalamus.
It can be seen that cynomorium total flavone can significantly improve the behavior indicators of rat with perimenopausal depression; obviously or significantly change the level of related biomedical indexes in serum and brains of perimenopausal depressed rat; obviously or significantly increase the expression of ER/AR in related tissues of perimenopausal depressed rat; obviously or significantly increase the ERmRNA expression in hypothalamus.
Cynomorium total flavone can adjust hypothalamic-pituitary-gonadal axis by increasing E2, and make related biomedical indexes and hormone receptors tend to be normal, so as to relieve perimenopausal syndrome and perimenopausal syndrome with depression.
观察锁阳总黄酮对围绝经期大鼠抑郁模型的影响，分析锁阳总黄酮对围绝经期综合征伴抑郁大鼠抑郁状态的作用特点。
采用不完全去势与慢性刺激相结合的方法复制围绝经期抑郁大鼠模型，并给药35天。然后检测相关行为学指标以及血清和脑组织中生化指标水平的变化；检测相关组织中雌激素/雄激素受体（ER/AR）及下丘脑ERmRNA表达。
结果显示，锁阳总黄酮可显著改善围绝经期抑郁大鼠的行为学指标；明显或显著改变围绝经期抑郁大鼠血清和脑组织中相关生物医学指标水平；明显或显著增加围绝经期抑郁大鼠相关组织中ER/AR的表达；明显或显著增加下丘脑ERmRNA表达。
锁阳总黄酮可通过升高E2调节下丘脑-垂体-性腺轴，使相关生物医学指标及激素受体趋于正常，从而缓解围绝经期综合征及围绝经期伴抑郁综合征。
