绵羊和牛C型白血病病毒诱导的合胞体形成的交叉中和作用。
Cross-neutralization of ovine and bovine C-type leukemia virus-induced syncytia formation.
作者信息
Ogura H, Paulsen J, Bauer H
出版信息
Cancer Res. 1977 May;37(5):1486-9.
PMID:192452
Abstract
Ovine leukemia virus (OLV) could not be distinguished from bovine leukemia virus (BLV) morphologically. Both C-type RNA tumor virus-producing cells induced syncytia when cocultivated with several indicator cells including XC and KC cells. Syncytia formation could be blocked by antibodies against OLV and BLV, indicating that fusion was virus mediated. Furthermore, antibodies against OLV and BLV exhibited reciprocal syncytial blocking properties, suggesting that OLV and BLV were closely related viruses.
摘要
绵羊白血病病毒（OLV）在形态上无法与牛白血病病毒（BLV）区分开来。当与包括XC和KC细胞在内的几种指示细胞共培养时，这两种产生C型RNA肿瘤病毒的细胞都会诱导形成多核巨细胞。针对OLV和BLV的抗体可以阻断多核巨细胞的形成，这表明融合是由病毒介导的。此外，针对OLV和BLV的抗体表现出相互的多核巨细胞阻断特性，这表明OLV和BLV是密切相关的病毒。
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