Wigger-Alberti W, Kuhlmann M, Ekanayake S, Wilhelm D
proDERM Institute for Applied Dermatological Research, Schenefeld-Hamburg, Germany.
J Wound Care. 2009 Mar;18(3):123-28, 131. doi: 10.12968/jowc.2009.18.3.39813.
To establish a new wound model that can induce uniform abrasions and use it to assess the healing properties of a range of products commonly applied to these wounds.
Ten healthy volunteers were enrolled into an open-label, randomised, intra-individual comparison pilot study. Five standardised, superficial abrasions were induced on their forearms by repeatedly scrubbing the skin with a surgical brush until the first signs of uniform glistening and punctuate bleeding were observed. Three products that promote a moist wound environment (polyurethane, hydrocolloid, hydrogel) and two standard plasters were randomly allocated to the test areas.
Evaluation of wound healing on days 2, 5, 8 and 14 +/- 1 showed best results for the polyurethane and hydrocolloid plasters. Visible re-epithelialisation was recorded on days 5 and 8. More than 50% of the wound area had closed. Video microscope images support these findings. The investigator and volunteers assessed cosmetic outcomes on day 31 +/- 2. Best results were obtained for the polyurethane and hydrocolloid products, which had high mean scores close to the maximum of 10. Histological examination of biopsies taken from the abrasions of two volunteers showed the dermis remained intact, making the model highly suitable for the study of superficial wounds.
Uniform and identical standardised wounds created using an abrasive brush technique can be used to reliably detect differences in the performance of plasters intended for superficial wounds. In general, products that promote a moist wound environment produced better results than those that promote a dry wound environment, with an earlier onset of healing and better healing outcomes. Superficial cutaneous wounds treated with polyurethane or hydrocolloid products demonstrated superior rates of re-epithelialisation and overall cosmetic outcomes.
This study was funded by Beiersdorf AG. Neither author has any interest in the sponsor's commercial activities.
建立一种能诱导均匀擦伤的新伤口模型，并利用该模型评估一系列常用于此类伤口的产品的愈合特性。
招募10名健康志愿者参与一项开放标签、随机、个体内比较的试点研究。用手术刷反复刷洗他们的前臂皮肤，直至观察到均匀发亮和点状出血的最初迹象，从而在前臂上造成5处标准化的浅表擦伤。将三种促进伤口湿润环境的产品（聚氨酯、水胶体、水凝胶）和两种标准创可贴随机分配到测试区域。
在第2、5、8和14±1天对伤口愈合情况进行评估，结果显示聚氨酯和水胶体创可贴效果最佳。在第5天和第8天记录到可见的上皮再形成。超过50%的伤口面积已愈合。视频显微镜图像支持这些结果。研究者和志愿者在第31±2天评估了美容效果。聚氨酯和水胶体产品获得了最佳结果，其平均得分较高，接近满分10分。对两名志愿者擦伤处活检组织的组织学检查显示真皮保持完整，这使得该模型非常适合用于浅表伤口的研究。
使用磨砂刷技术创建的均匀且相同的标准化伤口可用于可靠地检测用于浅表伤口的创可贴性能差异。一般来说，促进伤口湿润环境的产品比促进伤口干燥环境的产品效果更好，愈合开始更早且愈合效果更佳。用聚氨酯或水胶体产品治疗的浅表皮肤伤口显示出更高的上皮再形成率和整体美容效果。
本研究由拜尔斯道夫股份公司资助。两位作者均与赞助商的商业活动无任何利益关系。
