Nilforoushzadeh M A, Shirani-Bidabadi L, Zolfaghari-Baghbaderani A, Saberi S, Siadat A H, Mahmoudi M
Skin Diseases and Leishmaniasis Research Center (Sedigheh Tahereh), Isfahan University of Medical Sciences, Isfahan, Iran.
J Vector Borne Dis. 2008 Dec;45(4):301-6.
BACKGROUND & OBJECTIVES: Leishmaniasis is a parasitic disease transmitted by sand flies. Many investigations are performed to find an effective and safe treatment for leishmaniasis. In this study, we evaluated the efficacy of herbal extracts of Thymus vulgaris (Thyme) and Achillea millefolium (Yarrow), propolis hydroalcoholic extract and systemic glucantime against cutaneous leishmaniasis in Balb/c mice.
A total of 45 mice were randomised into five groups each including nine mice. They were treated with pure ethanol 70 degrees, systemic glucantime, Achillea millefolium hydroalcoholic extract, Thymus vulgaris hydroalcoholic extract and propolis hydroalcoholic extract for six weeks. The statistical tests including student t-test were used for analysis. Data were analyzed by SPSS software, ver 13.00.
Mean of ulcer size reduction were -17.66, -22.57, 43.29, 36.09 and 43.77% for the alcohol, glucantime, yarrow, thyme and propolis groups, respectively. The results were suggestive that Thymus vulgaris, Achillea millefolium and propolis hydroalcoholic extracts were significantly more effective in reduction of ulcer size as compared with glucantime (p = 0.006, 0.002 and 0.008, respectively).
INTERPRETATION & CONCLUSION: Our results are suggestive that Thymus vulgaris, Achillea millefolium and propolis extracts are effective for treatment of cutaneous leishmaniasis in mice. Regarding these results, we suggest that efficacy of these extracts alone or in combination are evaluated against human cutaneous leishmaniasis as a randomized clinical trial.
利什曼病是一种由白蛉传播的寄生虫病。人们进行了许多研究以寻找一种有效且安全的利什曼病治疗方法。在本研究中，我们评估了百里香（Thymus vulgaris）和蓍草（Achillea millefolium）的草药提取物、蜂胶水醇提取物以及全身使用葡糖胺锑钠对Balb/c小鼠皮肤利什曼病的疗效。
总共45只小鼠被随机分为五组，每组9只。它们分别用70度纯乙醇、全身使用葡糖胺锑钠、蓍草水醇提取物、百里香水醇提取物和蜂胶水醇提取物治疗六周。使用包括学生t检验在内的统计检验进行分析。数据通过SPSS软件13.00版进行分析。
酒精组、葡糖胺锑钠组、蓍草组、百里香组和蜂胶组溃疡大小减少的平均值分别为-17.66%、-22.57%、43.29%、36.09%和43.77%。结果表明，与葡糖胺锑钠相比，百里香、蓍草和蜂胶的水醇提取物在减少溃疡大小方面显著更有效（p值分别为0.006、0.002和0.008）。
我们的数据表明，百里香、蓍草和蜂胶提取物对小鼠皮肤利什曼病有效。基于这些结果，我们建议作为一项随机临床试验评估这些提取物单独或联合使用对人类皮肤利什曼病的疗效。
