伊朗本土植物治疗皮肤利什曼病：一项叙述性综述。
Iranian Native Plants on Treatment of Cutaneous Leishmaniosis: A Narrative Review.
作者信息
Moghaddas Elham, Khamesipour Ali, Mohebali Mehdi, Fata Abdolmajid
机构信息
Dept. of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Parasitol. 2017 Jul-Sep;12(3):312-322.
BACKGROUND
Chemotherapy still relies on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosin, and allopurinol. In this study, we explained about the native plant that grows in different regions of Iran and used as anti-leishmanial in Iran and even many other countries.
METHODS
This narrative review covers all information about local herbal medicine in Iran that used in treatment of cutaneous leishmaniasis in all the worlds, published in local and international journals from 1996 to 2015 using various databases including PubMed, SID, Google Scholar, Scopus, and Science Direct.
RESULTS
Overall, 150 articles in databases were identified. Many local plants grown in some places of Iran were used to treat this endemic disease.
CONCLUSION
The cutaneous leishmaniasis is also a major health problem in Iran, especially in Mashhad (Northeast of Iran). Therefore, many patients seek for herbal therapy that is cheaper and readily available. This review provides information regarding plant that exists in Iran and exhibiting effects on anti- activity. Among the anti-leishmanial mentioned in this review, most have never been tested for cytotoxicity and very few have been tested for in vivo activity.
背景
化疗仍然依赖于使用五价锑剂、两性霉素B、巴龙霉素、米替福新和别嘌呤醇。在本研究中，我们阐述了生长于伊朗不同地区、在伊朗乃至许多其他国家用作抗利什曼原虫药物的本土植物。
方法
本叙述性综述涵盖了1996年至2015年期间发表在国内外期刊上的、利用包括PubMed、SID、谷歌学术、Scopus和科学Direct在内的各种数据库检索到的、关于伊朗用于治疗全球皮肤利什曼病的当地草药的所有信息。
结果
数据库中总共识别出150篇文章。伊朗一些地方生长的许多当地植物被用于治疗这种地方病。
结论
皮肤利什曼病在伊朗也是一个主要的健康问题，尤其是在马什哈德（伊朗东北部）。因此，许多患者寻求更便宜且容易获得的草药疗法。本综述提供了有关伊朗存在的、具有抗利什曼原虫活性的植物的信息。在本综述提及的抗利什曼原虫药物中，大多数从未进行过细胞毒性测试，很少有进行过体内活性测试的。
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