伊朗具有潜在抗利什曼原虫活性的药用植物：系统评价与荟萃分析
Medicinal plants with promising antileishmanial activity in Iran: a systematic review and meta-analysis.
作者信息
Soosaraei Masoud, Fakhar Mahdi, Hosseini Teshnizi Saeed, Ziaei Hezarjaribi Hajar, Banimostafavi Elham Sadat
机构信息
Student Research Committee, Department of Parasitology and Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Molecular and Cell Biology Research Center, Department of Parasitology and Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Ann Med Surg (Lond). 2017 Jul 27;21:63-80. doi: 10.1016/j.amsu.2017.07.057. eCollection 2017 Sep.
BACKGROUND
Leishmaniasis is a major public health problem worldwide. The aim of the present study was to investigate medicinal plants with anti- activity which used in Iran.
METHODS
Data were systematically gathered from five English databases including Ebsco, Science Direct, PubMed, Google Scholar and Scopus, four Persian databases including Magiran, Iran doc, Iran medex and the Scientific Information Database (SID) from 1999 to April 2015. Information obtained included plant family, extraction method, concentrations of extracts, animal models and parasite strains.
RESULTS
A total of 68 articles including 188 experiments (140 in vitro and 48 in vivo) between 1999 and 2015, met our eligibility criteria. Thoroughly, 98 types of plants were examined against three genera of spp. For the heterogeneity study conducted, it was showed that there was a great deal of variation among studies. Based on random effect, meta-analysis pooled mean of IC50 was obtained 456.64 (95% CI: 396.15, 517.12).
CONCLUSION
The most Iranian plants used as anti-leishmanial activity were , , , and . The present systematic and meta-analysis review provide valuable information about natural products with anti- activity, which would be examined in the future experimental and clinical trials and herbal combination therapy.
背景
利什曼病是全球主要的公共卫生问题。本研究的目的是调查伊朗使用的具有抗利什曼活性的药用植物。
方法
从包括Ebsco、Science Direct、PubMed、谷歌学术和Scopus在内的五个英文数据库以及包括Magiran、Iran doc、Iran medex和科学信息数据库（SID）在内的四个波斯文数据库中系统收集1999年至2015年4月的数据。获得的信息包括植物科、提取方法、提取物浓度、动物模型和寄生虫菌株。
结果
1999年至2015年间共有68篇文章，包括188项实验（140项体外实验和48项体内实验）符合我们的纳入标准。总共对98种植物针对三种利什曼原虫属进行了检测。对于所进行的异质性研究，结果表明各研究之间存在很大差异。基于随机效应，荟萃分析得出IC50的合并均值为456.64（95%可信区间：396.15，517.12）。
结论
伊朗最常用于抗利什曼活性的植物是[此处原文缺失具体植物名称]、[此处原文缺失具体植物名称]、[此处原文缺失具体植物名称]、[此处原文缺失具体植物名称]和[此处原文缺失具体植物名称]。本系统评价和荟萃分析提供了有关具有抗利什曼活性的天然产物的有价值信息，这些信息将在未来的实验和临床试验以及草药联合治疗中进行检验。
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