Pan An, Lu Ling, Franco Oscar H, Yu Zhijie, Li Huaixing, Lin Xu
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, 200031, China.
J Affect Disord. 2009 Nov;118(1-3):240-3. doi: 10.1016/j.jad.2009.02.002. Epub 2009 Feb 27.
Vitamin D deficiency is recently speculated to play a role in the development of depression. Nevertheless, few studies have explored the association between blood 25-hydroxyvitamin D [25(OH)D] concentrations and depression in the general population. Therefore, we aimed to determine this association in middle-aged and elderly Chinese.
We conducted a population-based cross-sectional study in 2005 in Beijing and Shanghai, China. Participants included 3262 community residents aged 50-70. Depressive symptoms were defined as a Center for Epidemiological Studies of Depression Scale (CES-D) score of 16 or higher. Circulating 25(OH)D concentrations were measured by radioimmunoassay.
The prevalence of depressive symptoms was lower in the top tertile of 25(OH)D concentrations compared to the lowest tertile (7.2% vs. 11.1%) in the study population (odds ratio, 0.62; 95% confidence interval, 0.46-0.83; P for trend=0.002). This association was substantially attenuated after controlling for various confounding factors, and disappeared after including geographic location in the model. Stratified analysis by location did not find any association between depressive symptoms and 25(OH)D levels among participants from either Beijing or Shanghai.
Due to the cross-sectional study design, causal relation remains unknown.
Depressive symptoms are not associated with 25(OH)D concentrations in middle-aged and elderly Chinese. Further prospective studies are required to determine whether they are correlated.
最近推测维生素D缺乏在抑郁症的发生发展中起作用。然而，很少有研究探讨普通人群血液中25-羟基维生素D[25(OH)D]浓度与抑郁症之间的关联。因此，我们旨在确定中国中老年人群中的这种关联。
2005年在中国北京和上海进行了一项基于人群的横断面研究。参与者包括3262名年龄在50至70岁之间的社区居民。抑郁症状定义为流行病学研究中心抑郁量表（CES-D）得分16分或更高。采用放射免疫分析法测定循环25(OH)D浓度。
在研究人群中，25(OH)D浓度最高三分位数组的抑郁症状患病率低于最低三分位数组（7.2%对11.1%）（优势比，0.62；95%置信区间，0.46-0.83；趋势P=0.002）。在控制各种混杂因素后，这种关联显著减弱，在模型中纳入地理位置后消失。按地理位置进行分层分析未发现北京或上海的参与者中抑郁症状与25(OH)D水平之间存在任何关联。
由于横断面研究设计，因果关系尚不清楚。
中国中老年人群的抑郁症状与25(OH)D浓度无关。需要进一步的前瞻性研究来确定它们是否相关。
