Boyd L A, Edwards J D, Siengsukon C S, Vidoni E D, Wessel B D, Linsdell M A
Department of Physical Therapy, Neurobiology of Motor Learning, University of British Columbia, British Columbia, Canada.
Neurobiol Learn Mem. 2009 Jul;92(1):35-44. doi: 10.1016/j.nlm.2009.02.009. Epub 2009 Feb 26.
Our main aim was to determine whether individuals with stroke that affected the basal ganglia, organized movement sequences into chunks in the same fashion as neurologically intact individuals. To address this question, we compared motor response times during the performance of repeated sequences that were learned, and thus may be planned in advance, with random sequences where there is minimal if any advance preparation or organization of responses. The pattern of responses illustrated that, after basal ganglia stroke, individuals do not chunk elements of the repeated sequence into functional sub-sequences of movement to the same extent as neurologically intact age-matched people. Limited chunking of learned movements after stroke may explain past findings that show overall slower responses even when sequences of action are learned by this population. Further, our data in combination with other work, suggest that chunking may be a function of the basal ganglia.
我们的主要目的是确定影响基底神经节的中风患者是否会像神经功能正常的个体一样，以相同的方式将运动序列组织成组块。为了解决这个问题，我们比较了在执行已学习的重复序列（因此可能是预先计划好的）时的运动反应时间，以及在随机序列（其中几乎没有或根本没有预先准备或反应组织）时的运动反应时间。反应模式表明，基底神经节中风后，个体不会像神经功能正常的同龄人那样，将重复序列的元素同样程度地组织成功能性运动子序列。中风后所学运动的组块受限，这可能解释了过去的研究结果，即即使这个群体学会了动作序列，其整体反应速度仍较慢。此外，我们的数据与其他研究相结合表明，组块可能是基底神经节的一项功能。
