MicroRNAs suggest a new mechanism for altered brain gene expression in schizophrenia.
作者信息
Coyle Joseph T
机构信息
Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA.
出版信息
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):2975-6. doi: 10.1073/pnas.0813321106. Epub 2009 Feb 26.
Abstract
摘要
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An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.一种活性调节的微小RNA通过下调p250GAP来控制树突可塑性。
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9093-8. doi: 10.1073/pnas.0803072105. Epub 2008 Jun 24.
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Dysregulation of miRNA 181b in the temporal cortex in schizophrenia.精神分裂症患者颞叶皮质中miRNA 181b的失调
Hum Mol Genet. 2008 Apr 15;17(8):1156-68. doi: 10.1093/hmg/ddn005. Epub 2008 Jan 9.
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Members of the miRNA-200 family regulate olfactory neurogenesis.微小RNA-200家族的成员调节嗅觉神经发生。
Neuron. 2008 Jan 10;57(1):41-55. doi: 10.1016/j.neuron.2007.11.018.
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microRNA modulation of circadian-clock period and entrainment.微小RNA对昼夜节律周期和同步的调节
Neuron. 2007 Jun 7;54(5):813-29. doi: 10.1016/j.neuron.2007.05.017.
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The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia.盘状结构域受体1作为精神分裂症的一种新型易感基因。
Mol Psychiatry. 2007 Sep;12(9):833-41. doi: 10.1038/sj.mp.4001995. Epub 2007 Apr 17.
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Glutamate and schizophrenia: beyond the dopamine hypothesis.谷氨酸与精神分裂症：超越多巴胺假说
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A pharmacological model for psychosis based on N-methyl-D-aspartate receptor hypofunction: molecular, cellular, functional and behavioral abnormalities.基于N-甲基-D-天冬氨酸受体功能减退的精神病药理学模型：分子、细胞、功能及行为异常
Biol Psychiatry. 2006 Apr 15;59(8):721-9. doi: 10.1016/j.biopsych.2005.08.029. Epub 2006 Jan 19.
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The Elegance of the MicroRNAs: A Neuronal Perspective.微小RNA的精妙之处：从神经元角度看
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