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对接受手术和非手术治疗的重症创伤患者实施缩短禁食方案的可行性。

Feasibility of implementing a reduced fasting protocol for critically ill trauma patients undergoing operative and nonoperative procedures.

作者信息

Pousman Robert M, Pepper Colleen, Pandharipande Pratik, Ayers Gregory D, Mills Beth, Diaz Jose, Collier Brian, Miller Rick, Jensen Gordon

机构信息

Department of Anesthesiology, David Geffen School of Medicine at UCLA, West Los Angeles VA, Los Angeles, California, USA.

出版信息

JPEN J Parenter Enteral Nutr. 2009 Mar-Apr;33(2):176-80. doi: 10.1177/0148607108327527.

Abstract

BACKGROUND

This prospective, observational cohort study was designed to determine the feasibility of implementing a reduced enteral fasting protocol in mechanically ventilated trauma patients undergoing selected operative and nonoperative procedures.

METHODS

Critically ill, mechanically ventilated trauma patients undergoing selected operative and nonoperative procedures received enteral nutrition up until the time of the procedure, if receiving small bowel feeds, or received enteral nutrition that was discontinued 45 minutes before the procedure, if receiving gastric feeds.

RESULTS

Measures of delivery of nutrition such as total enteral nutrition delivered and days required to reach nutrition goal were collected. Complications measured were death, incidence of ventilator-associated pneumonia, urinary tract infection, catheter-related bloodstream infection, wound infection, hypoglycemia, and emesis during procedures. No significant demographic differences were observed between the 2 groups. Patients in the intervention group showed trends toward greater total enteral nutrition delivered and faster attainment of target nutrition goals, although these measures were not statistically significant. Patients in the intervention group had rates of infective complications similar to those in the standard group. The median (interquartile range) for intensive care unit length of stay in the intervention group vs standard group was 7 (5, 15) vs 7 (5, 12) (P = 0.94), and the ventilator days were 8 (4.2, 14) vs 7 (3, 11) (P = 0.37).

CONCLUSIONS

A reduced fasting protocol was feasible for selected operative procedures, with trends toward improving nutrition delivery and no increase in adverse outcomes. A larger randomized study of this approach is warranted before adoption of this practice can be advocated.

摘要

背景

本前瞻性观察性队列研究旨在确定在接受特定手术和非手术治疗的机械通气创伤患者中实施减少肠内禁食方案的可行性。

方法

病情严重、接受机械通气且正在接受特定手术和非手术治疗的创伤患者,如果接受小肠喂养,则在手术前一直接受肠内营养;如果接受胃喂养,则在手术前45分钟停止肠内营养。

结果

收集了营养输送的相关指标,如总肠内营养输送量和达到营养目标所需的天数。所测量的并发症包括死亡、呼吸机相关性肺炎发病率、尿路感染、导管相关血流感染、伤口感染、低血糖以及手术期间的呕吐。两组之间未观察到显著的人口统计学差异。干预组患者在总肠内营养输送量和更快实现目标营养目标方面呈现出增加的趋势,尽管这些指标在统计学上并不显著。干预组患者的感染性并发症发生率与标准组相似。干预组与标准组在重症监护病房住院时间的中位数(四分位间距)分别为7(5,15)天和7(5,12)天(P = 0.94),呼吸机使用天数分别为8(4.2,14)天和7(3,11)天(P = 0.37)。

结论

减少禁食方案对于特定手术是可行的,在改善营养输送方面有趋势,且不良结局未增加。在提倡采用这种做法之前,有必要对这种方法进行更大规模的随机研究。

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